3.0
Summary
| Name |  PHF20View Modifications |
| Full Name | PHD finger protein 20 |
| Synonyms | Glioma-expressed antigen 2, Hepatocellular carcinoma-associated antigen 58, Novel zinc finger protein, Transcription factor TZP | C20orf104, GLEA2, HCA58, NZF, TZP |
| Primary ID | Q9BVI0 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | Methyllysine-binding protein, component of the MOF histone acetyltransferase protein complex. Not required for maintaining the global histone H4 'Lys-16' acetylation (H4K16ac) levels or locus specific histone acetylation, but instead works downstream in transcriptional regulation of MOF target genes (By similarity). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Contributes to methyllysine-dependent p53/TP53 stabilization and up-regulation after DNA damage. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | AKT | down-regulates 
phosphorylation
|
PHF20 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | AKT1 | down-regulates
phosphorylation
|
PHF20 | 0.533 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PHF20 | form complex 
binding
|
NSL histone acetyltransferase | 0.67 |
| Publications: | 1 | Organism: | Homo Sapiens | |