| + |
ABL1 | up-regulates activity 
phosphorylation
|
SORBS1 |
0.43 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278153 |
Tyr326 |
Y-->S |
Homo sapiens |
|
| pmid |
sentence |
| 19891780 |
We have here identified Tyr360 in CAP as a major phosphorylation site by c-Abl, although Tyr 632 also might contribute since its substitution in combination with the Y360F mutation reduced the phosphorylation of CAP to a very low level. Y360 in CAP is the major phosphorylation site of c-Abl. Since Tyr326 was not a major c-Abl phosphorylation site, we sought to identify a putative other kinase that might be involved in the phosphorylation of Y326 in CAP. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278152 |
Tyr360 |
Y-->K |
Homo sapiens |
|
| pmid |
sentence |
| 19891780 |
We have here identified Tyr360 in CAP as a major phosphorylation site by c-Abl, although Tyr 632 also might contribute since its substitution in combination with the Y360F mutation reduced the phosphorylation of CAP to a very low level. Y360 in CAP is the major phosphorylation site of c-Abl. Since Tyr326 was not a major c-Abl phosphorylation site, we sought to identify a putative other kinase that might be involved in the phosphorylation of Y326 in CAP. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278154 |
Tyr632 |
Y-->N |
Homo sapiens |
|
| pmid |
sentence |
| 19891780 |
We have here identified Tyr360 in CAP as a major phosphorylation site by c-Abl, although Tyr 632 also might contribute since its substitution in combination with the Y360F mutation reduced the phosphorylation of CAP to a very low level. Y360 in CAP is the major phosphorylation site of c-Abl. Since Tyr326 was not a major c-Abl phosphorylation site, we sought to identify a putative other kinase that might be involved in the phosphorylation of Y326 in CAP. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
SORBS1 | up-regulates
binding
|
CBL |
0.68 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-82283 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11001060 |
Cbl is recruited to the insulin receptor by interaction with the adapter protein cap, through one of three adjacent sh3 domains in the carboxy terminus of cap |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle |
3.0
SORBS1
- 
- 