Summary

Name CBL
Full Name E3 ubiquitin-protein ligase CBL
Synonyms Casitas B-lineage lymphoma proto-oncogene, Proto-oncogene c-Cbl, RING finger protein 55, Signal transduction protein CBL | CBL2, RNF55
Primary ID P22681
Links - -
Type protein
Relations 50
Pathways Acute Myeloid Leukemia, FLT3 in AML, KIT in AML, Glioblastoma Multiforme
Function Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome (PubMed:17094949). Ubiquitinates SPRY2 (PubMed:17094949, PubMed:17974561). Ubiquitinates EGFR (PubMed:17974561). Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation. Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis. Essential for osteoclastic bone resorption. The 'Tyr-731' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBLB, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity).

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates quantity img/direct_inhibition.png phosphorylation CBL 0.326
Publications: 4 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation CBL 0.396
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CBL 0.5
Publications: 3 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation CBL 0.801
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination PDGFRB 0.609
Publications: 2 Organism: Mus Musculus, Homo Sapiens
+ up-regulates img/direct-activation.png relocalization CBL 0.88
Publications: 2 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, Glioblastoma Multiforme
+ up-regulates img/direct-activation.png binding CBL 0.373
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding CBL 0.591
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding CBL 0.379
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png ubiquitination CBL 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png ubiquitination PIK3R1 0.674
Publications: 1 Organism: Homo Sapiens
Pathways:Glioblastoma Multiforme
+ up-regulates img/direct-activation.png binding CBL 0.672
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ down-regulates img/direct_inhibition.png ubiquitination SORBS2 0.53
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination ABL1 0.608
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination PDGFRA 0.464
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png binding CBL 0.456
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination ERBB2 0.622
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png ubiquitination KIT 0.597
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, KIT in AML
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination EGFR 0.88
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, Glioblastoma Multiforme
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination LCK 0.696
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png ubiquitination FRS2 0.553
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding CBL 0.679
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding FLT3 0.449
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, FLT3 in AML
+ up-regulates img/direct-activation.png phosphorylation CBL 0.375
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png binding EPHA2 0.618
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png ubiquitination PI3K 0.588
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3 in AML, KIT in AML
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination CFLAR 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding CBL 0.814
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CBL 0.361
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png relocalization CBL 0.9
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia, FLT3 in AML, KIT in AML, Glioblastoma Multiforme
+ down-regulates activity img/indirect_inhibition.png CBL 0.331
Publications: 1 Organism: Homo Sapiens
Pathways:Acute Myeloid Leukemia
+ img/unknown.png phosphorylation CBL 0.649
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png binding CBL 0.628
Publications: 2 Organism: Cricetulus Griseus, Homo Sapiens
Tissue: Ovary
+ down-regulates img/direct_inhibition.png ubiquitination INSR 0.5
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding CBL 0.736
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png ubiquitination LRIG1 0.568
Publications: 1 Organism: Homo Sapiens
Tissue: Skin
+ up-regulates activity img/direct-activation.png monoubiquitination MYCBPAP 0.301
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png ubiquitination PIK3R2 0.583
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding CBL 0.568
Publications: 1 Organism: Homo Sapiens
Tissue: Skin
+ down-regulates activity img/direct_inhibition.png ubiquitination SYK 0.806
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination MET 0.716
Publications: 1 Organism: Homo Sapiens