4.0
Summary
| Name |  KDM5DView Modifications |
| Full Name | Lysine-specific demethylase 5D |
| Synonyms | Histocompatibility Y antigen, H-Y, Histone demethylase JARID1D, Jumonji/ARID domain-containing protein 1D, Protein SmcY, [histone H3]-trimethyl-L-lysine(4) demethylase 5D | HY, HYA, JARID1D, KIAA0234, SMCY |
| Primary ID | Q9BY66 |
| Links |  -  -  |
| Type | protein |
| Relations | 5 |
| Function | Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May play a role in spermatogenesis. Involved in transcriptional repression of diverse metastasis-associated genes; in this function seems to cooperate with ZMYND8. Suppresses prostate cancer cell invasion. Regulates androgen receptor (AR) transcriptional activity by demethylating H3K4me3 active transcription marks. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | KDM5D | up-regulates activity 
demethylation
|
H3C1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | KDM5D | up-regulates activity
demethylation
|
H3-3A | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | KDM5D | up-regulates activity
demethylation
|
H3-4 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | 2-oxoglutarate(2-) | up-regulates activity
chemical activation
|
KDM5D | 0.8 |
| Publications: | 1 | |||
| + | KDM5D | up-regulates activity
demethylation
|
Histone H3 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |