Summary

Name KDM5D
Full Name Lysine-specific demethylase 5D
Synonyms Histocompatibility Y antigen, H-Y, Histone demethylase JARID1D, Jumonji/ARID domain-containing protein 1D, Protein SmcY, [histone H3]-trimethyl-L-lysine(4) demethylase 5D | HY, HYA, JARID1D, KIAA0234, SMCY
Primary ID Q9BY66
Links - -
Type protein
Relations 5
Function Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May play a role in spermatogenesis. Involved in transcriptional repression of diverse metastasis-associated genes; in this function seems to cooperate with ZMYND8. Suppresses prostate cancer cell invasion. Regulates androgen receptor (AR) transcriptional activity by demethylating H3K4me3 active transcription marks.

Viewer

Search Tools

Refine search:

  • by mechanism


  • by effect
  • by organism:


  • by tissue:


  • by cell-line

▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ KDM5Dup-regulates activity img/direct-activation.png demethylation H3C1 0.2
Publications: 1 Organism: Homo Sapiens
+ KDM5Dup-regulates activity img/direct-activation.png demethylation H3-4 0.2
Publications: 1 Organism: Homo Sapiens
+ KDM5Dup-regulates activity img/direct-activation.png demethylation H3-3A 0.2
Publications: 1 Organism: Homo Sapiens
+ KDM5Dup-regulates activity img/direct-activation.png demethylation Histone H3 0.2
Publications: 1 Organism: Homo Sapiens
+ 2-oxoglutarate(2-)up-regulates activity img/direct-activation.png chemical activation KDM5D 0.8
Publications: 1