+ |
STK33 | down-regulates quantity by destabilization
phosphorylation
|
HPD |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-272958 |
Thr382 |
QNLRGNLtNMETNGV |
Mus musculus |
Hippocampal Cell Line |
pmid |
sentence |
31537781 |
Decreased expression of 4-hydroxyphenylpyruvic acid dioxygenase (HPD), a key enzyme for tyrosine metabolism, is a cause of human tyrosinemia. However, the regulation of HPD expression remains largely unknown. Here, we demonstrate that molecular chaperone TTC36, which is highly expressed in liver, is associated with HPD and reduces the binding of protein kinase STK33 to HPD, thereby inhibiting STK33-mediated HPD T382 phosphorylation. The reduction of HPD T382 phosphorylation results in impaired recruitment of FHA domain-containing PELI1 and PELI1-mediated HPD polyubiquitylation and degradation. |
|
Publications: |
1 |
Organism: |
Mus Musculus |
+ |
STK33 | up-regulates quantity by stabilization
phosphorylation
|
AKAP4 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-272956 |
|
|
in vitro |
|
pmid |
sentence |
37146716 |
Differential phosphoproteomic analysis and in vitro kinase assay identified novel phosphorylation substrates of STK33, fibrous sheath components AKAP3 and AKAP4, whose expression levels decreased in testis after deletion of Stk33. |
|
Publications: |
1 |
Organism: |
In Vitro |
+ |
STK33 | up-regulates quantity by stabilization
phosphorylation
|
AKAP3 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-272955 |
|
|
in vitro |
|
pmid |
sentence |
37146716 |
Differential phosphoproteomic analysis and in vitro kinase assay identified novel phosphorylation substrates of STK33, fibrous sheath components AKAP3 and AKAP4, whose expression levels decreased in testis after deletion of Stk33. |
|
Publications: |
1 |
Organism: |
In Vitro |
+ |
STK33 | up-regulates activity
phosphorylation
|
STK33 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-272957 |
|
|
|
|
pmid |
sentence |
18811945 |
Our results show that the serine/threonine kinase Stk33 phosphorylates the intermediate filament protein vimentin in vitro specifically in the vimentin head domain. Stk33 undergoes obligatory autophosphorylation, which might be a prerequisite for its kinasing activity. |
|
Publications: |
1 |