Relation Results

Summary

Name NUF2
Full Name Kinetochore protein Nuf2
Synonyms hNuf2, hNuf2R, hsNuf2, Cell division cycle-associated protein 1 | CDCA1, NUF2R
Primary ID Q9BZD4
Links - -
Type protein
Relations 2
Function Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activit ...
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Type: Score: Layout: SPV 
0.20.974CDR2NUF2Ndc80 complex

Relations

Regulator
Mechanism
target
score
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NUF2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-252022
pmid sentence
Additionally, cdr2 knockdown lead to a decrease (Table 3) in four other transcripts (AURKA, CENPE, SPC25 and TTK), which are involved in kinetochore and spindle biology
Publications: 1
+ form complex img/form-complex.png binding Ndc80 complex 0.974
Identifier Residue Sequence Organism Cell Line
SIGNOR-265187
pmid sentence
Kinetochores, multisubunit protein assemblies, connect chromosomes to spindle microtubules to promote chromosome segregation. The 10-subunit KMN assembly (comprising KNL1, MIS12, and NDC80 complexes, designated KNL1C, MIS12C, and NDC80C) binds microtubules and regulates mitotic checkpoint function through NDC80C and KNL1C, respectively. |NDC80C contains the NDC80, NUF2, SPC24, and SPC25 subunits
Publications: 1
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