| + |
CDR2 | up-regulates quantity by expression 
transcriptional regulation
|
CENPE |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252020 |
|
|
|
|
| pmid |
sentence |
| 20383333 |
Additionally, cdr2 knockdown lead to a decrease (Table 3) in four other transcripts (AURKA, CENPE, SPC25 and TTK), which are involved in kinetochore and spindle biology |
|
| Publications: |
1 |
| + |
CDR2 | up-regulates activity 
binding
|
MYC |
0.516 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252000 |
|
|
|
|
| pmid |
sentence |
| 20383333 |
Here we find that cdr2 is cell cycle regulated in tumor cells with protein levels peaking in mitosis. As cells exit mitosis, cdr2 is ubiquitinated by the anaphase promoting complex/cyclosome (APC/C) and rapidly degraded by the proteasome. Previously we showed that cdr2 binds to the oncogene c-myc, and here we extend this observation to show that cdr2 and c-myc interact to synergistically regulate c-myc-dependent transcription during passage through mitosis. |
|
| Publications: |
1 |
| + |
CDR2 | up-regulates quantity by expression
transcriptional regulation
|
TTK |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252021 |
|
|
|
|
| pmid |
sentence |
| 20383333 |
Additionally, cdr2 knockdown lead to a decrease (Table 3) in four other transcripts (AURKA, CENPE, SPC25 and TTK), which are involved in kinetochore and spindle biology |
|
| Publications: |
1 |
| + |
CDR2 | up-regulates quantity by expression
transcriptional regulation
|
NUF2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252022 |
|
|
|
|
| pmid |
sentence |
| 20383333 |
Additionally, cdr2 knockdown lead to a decrease (Table 3) in four other transcripts (AURKA, CENPE, SPC25 and TTK), which are involved in kinetochore and spindle biology |
|
| Publications: |
1 |
| + |
APC-c | down-regulates quantity by destabilization 
ubiquitination
|
CDR2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252024 |
|
|
|
|
| pmid |
sentence |
| 20383333 |
Here we find that cdr2 is cell cycle regulated in tumor cells with protein levels peaking in mitosis. As cells exit mitosis, cdr2 is ubiquitinated by the anaphase promoting complex/cyclosome (APC/C) and rapidly degraded by the proteasome. Previously we showed that cdr2 binds to the oncogene c-myc, and here we extend this observation to show that cdr2 and c-myc interact to synergistically regulate c-myc-dependent transcription during passage through mitosis. |
|
| Publications: |
1 |
| + |
CDR2 | up-regulates quantity by expression
transcriptional regulation
|
AURKA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252023 |
|
|
|
|
| pmid |
sentence |
| 20383333 |
Additionally, cdr2 knockdown lead to a decrease (Table 3) in four other transcripts (AURKA, CENPE, SPC25 and TTK), which are involved in kinetochore and spindle biology |
|
| Publications: |
1 |
3.0
CDR2
- 
- 