+ |
AMPK | down-regulates
phosphorylation
|
PPP1R12C |
0.259 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-216600 |
Ser452 |
AGLQRSAsSSWLEGT |
Homo sapiens |
|
pmid |
sentence |
22137581 |
Ampk-induced phosphorylation is necessary for ppp1r12c interaction with 14-3-3 and phosphorylation of myosin regulatory light chain. Both ampk activity and ppp1r12c phosphorylation are increased in mitotic cells and are important for mitosis completion. The interaction between ppp1r12c and 14-3-3_ may inactivate the ppp1r12c-containing phosphatase complex in vivo. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
PRKAA2 | down-regulates
phosphorylation
|
PPP1R12C |
0.262 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-195148 |
Ser452 |
AGLQRSAsSSWLEGT |
Homo sapiens |
|
pmid |
sentence |
22137581 |
Ampk-induced phosphorylation is necessary for ppp1r12c interaction with 14-3-3 and phosphorylation of myosin regulatory light chain. Both ampk activity and ppp1r12c phosphorylation are increased in mitotic cells and are important for mitosis completion. The interaction between ppp1r12c and 14-3-3_ may inactivate the ppp1r12c-containing phosphatase complex in vivo. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
CDC42BPA | down-regulates activity
phosphorylation
|
PPP1R12C |
0.576 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-250724 |
Thr560 |
MRQSRRStQGVTLTD |
|
COS-7 Cell |
pmid |
sentence |
11399775 |
Identification of the Phosphorylation Site of p85 on Threonine 560 by MRCKα-CAT | Wild-type p85 but not the mutant p85AA, when phosphorylated in vitro with MRCKα-CAT, showed significant reduction in the rate of MLC2 dephosphorylation. These results confirm a similar observation with MBS130 where phosphorylation of a conserved threonine 695 within a highly conserved motif was essential for the inhibition of phosphatase catalytic activity |
|
Publications: |
1 |