| + |
CDC42BPA | up-regulates activity 
phosphorylation
|
MYL2 |
0.635 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250723 |
Ser19 |
GANSNVFsMFEQTQI |
|
HeLa Cell |
| pmid |
sentence |
| 9418861 |
These approximately 190-kDa myotonic dystrophy kinase-related Cdc42-binding kinases (MRCKs) preferentially phosphorylate nonmuscle myosin light chain at serine 19, which is known to be crucial for activating actin-myosin contractility. |
|
| Publications: |
1 |
| + |
CDC42BPA | up-regulates
phosphorylation
|
MYL9 |
0.531 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-188781 |
Ser20 |
KRPQRATsNVFAMFD |
Homo sapiens |
|
| pmid |
sentence |
| 19851336 |
More than a dozen kinases have been reported to phosphorylate the rlcs of nm ii (fig. 2), including myosin light chain kinase (mlck;also known as mylk), rho-associated, coiled coil-containing kinase (rock), citron kinase, leucine zipper interacting kinase (zipk;also known as dapk3) and myotonic dystrophy kinase-related cdc42-binding kinase (mrck;also known as cdc42bp)6,34,45,46. These kinases phosphorylate rlcs on ser19, thr18 or both, to relieve the inhibition imposed on the myosin molecule by unphosphorylated rlcs and the head_head interaction outlined above. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-188785 |
Thr19 |
KKRPQRAtSNVFAMF |
Homo sapiens |
|
| pmid |
sentence |
| 19851336 |
More than a dozen kinases have been reported to phosphorylate the rlcs of nm ii (fig. 2), including myosin light chain kinase (mlck;also known as mylk), rho-associated, coiled coil-containing kinase (rock), citron kinase, leucine zipper interacting kinase (zipk;also known as dapk3) and myotonic dystrophy kinase-related cdc42-binding kinase (mrck;also known as cdc42bp)6,34,45,46. These kinases phosphorylate rlcs on ser19, thr18 or both, to relieve the inhibition imposed on the myosin molecule by unphosphorylated rlcs and the head_head interaction outlined above. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
CDC42BPA | up-regulates activity
phosphorylation
|
CDC42BPA |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275974 |
Ser234 |
MEDGTVQsSVAVGTP |
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 11283256 |
N terminus-mediated dimerization and transautophosphorylation are essential for MRCKα catalytic activity. Three mutations, S234A, T240A, and T403A, strongly affected the in vitro autophosphorylation activity of FLAG-MRCKα-CAT1–473 (Fig. (Fig.5D).5D). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275975 |
Thr240 |
QSSVAVGtPDYISPE |
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 11283256 |
N terminus-mediated dimerization and transautophosphorylation are essential for MRCKα catalytic activity. Three mutations, S234A, T240A, and T403A, strongly affected the in vitro autophosphorylation activity of FLAG-MRCKα-CAT1–473 (Fig. (Fig.5D).5D). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275973 |
Thr403 |
HLPFVGFtYTSSCVL |
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 11283256 |
N terminus-mediated dimerization and transautophosphorylation are essential for MRCKα catalytic activity. Three mutations, S234A, T240A, and T403A, strongly affected the in vitro autophosphorylation activity of FLAG-MRCKα-CAT1–473 (Fig. (Fig.5D).5D). |
|
| Publications: |
3 |
Organism: |
Chlorocebus Aethiops |
| + |
CDC42BPA | up-regulates activity
phosphorylation
|
LIMK2 |
0.403 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-107584 |
Thr505 |
NDRKKRYtVVGNPYW |
Chlorocebus aethiops |
COS Cell |
| pmid |
sentence |
| 11340065 |
These results indicate that mrckalpha phosphorylates and activates lim kinases downstream of cdc42, which in turn regulates the actin cytoskeletal reorganization through the phosphorylation and inactivation of adf/cofilin. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
CDC42BPA | up-regulates activity
phosphorylation
|
LIMK1 |
0.413 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250721 |
Thr508 |
PDRKKRYtVVGNPYW |
|
HeLa Cell |
| pmid |
sentence |
| 11340065 |
Activation of LIM kinases by myotonic dystrophy kinase-related Cdc42-binding kinase alpha. \ In vitro, MRCKalpha phosphorylated the protein kinase domain of LIM kinases, and the site in LIMK2 phosphorylated by MRCKalpha proved to be threonine 505 within the activation segment. |
|
| Publications: |
1 |
| + |
CDC42BPA | down-regulates activity 
phosphorylation
|
PPP1R12C |
0.576 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250724 |
Thr560 |
MRQSRRStQGVTLTD |
|
COS-7 Cell |
| pmid |
sentence |
| 11399775 |
Identification of the Phosphorylation Site of p85 on Threonine 560 by MRCKα-CAT | Wild-type p85 but not the mutant p85AA, when phosphorylated in vitro with MRCKα-CAT, showed significant reduction in the rate of MLC2 dephosphorylation. These results confirm a similar observation with MBS130 where phosphorylation of a conserved threonine 695 within a highly conserved motif was essential for the inhibition of phosphatase catalytic activity |
|
| Publications: |
1 |
| + |
CDC42 | up-regulates activity
binding
|
CDC42BPA |
0.784 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262593 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 9418861 |
Myotonic dystrophy kinase-related Cdc42-binding kinase acts as a Cdc42 effector in promoting cytoskeletal reorganization|MRCK alpha and Cdc42V12 colocalize, particularly at the cell periphery in transfected HeLa cells. Microinjection of plasmid encoding MRCK alpha resulted in actin and myosin reorganization. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
CDC42BPA
- 
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