Relation Results

Summary

Name NLRP1
Full Name NACHT, LRR and PYD domains-containing protein 1
Synonyms Caspase recruitment domain-containing protein 7, Death effector filament-forming ced-4-like apoptosis protein, Nucleotide-binding domain and caspase recruitment domain | CARD7, DEFCAP, KIAA0926, NAC, NALP1
Primary ID Q9C000
Links - -
Type protein
Relations 3
Function As the sensor component of the NLRP1 inflammasome, plays a crucial role in innate immunity and inflammation. Inflammasomes are supramolecular complexe ...
View More

Viewer

Type: Score: Layout: SPV 
0.6420.70.7NLRP1NLRP1 inflammasomePAMPsDAMPS

Relations

Regulator
Mechanism
target
score
+ form complex img/form-complex.png binding NLRP1 inflammasome 0.642
Identifier Residue Sequence Organism Cell Line
SIGNOR-256407
pmid sentence
Canonical inflammasomes form activation platforms for caspase-1. Their assembly depends on some dedicated cytosolic PRRs from the nucleotide-binding domain leucin-rich repeat (NLR) family including NLR and pyrin domain containing receptor 1 (NLRP1), NLRP3, and NLR and caspase recruitment domain containing receptor 4 (NLRC4); the AIM2-like receptors (ALR) family including absent in melanoma 2 (AIM2); or the tripartite motif (TRIM) family including pyrin.
Publications: 1
+ up-regulates activity img/indirect-activation.png NLRP1 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-256425
pmid sentence
Among these sensors, members of the evolutionary conserved NLRs, together with AIM2 and pyrin, can assemble into a multimeric protein complex that is called the inflammasome (see poster).| An inflammasome assembles in response to a diverse range of pathogen-associated or danger-associated molecular patterns (PAMPs or DAMPs). The inflammasome platform leads to activation of caspase-1 through proximity-induced self-cleavage
Publications: 1
+ up-regulates activity img/indirect-activation.png NLRP1 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-256421
pmid sentence
Among these sensors, members of the evolutionary conserved NLRs, together with AIM2 and pyrin, can assemble into a multimeric protein complex that is called the inflammasome (see poster).| An inflammasome assembles in response to a diverse range of pathogen-associated or danger-associated molecular patterns (PAMPs or DAMPs). The inflammasome platform leads to activation of caspase-1 through proximity-induced self-cleavage
Publications: 1
a simple tooltip