+ |
ZDHHC5 | down-regulates activity
palmitoylation
|
EZH2 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-261144 |
|
|
Homo sapiens |
Glioma Cell |
pmid |
sentence |
28775165 |
Mechanistic investigations revealed that mutant p53 transcriptionally upregulated ZDHHC5 along with the nuclear transcription factor NF-Y. These events contributed to the development of glioma by promoting the self-renewal capacity and tumorigenicity of glioma stem-like cells, by altering the palmitoylation and phosphorylation status of the tumor suppressor EZH2. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
NFY | up-regulates quantity by expression
transcriptional regulation
|
ZDHHC5 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-261151 |
|
|
Homo sapiens |
|
pmid |
sentence |
28775165 |
Mechanistic investigations revealed that mutant p53 transcriptionally upregulated ZDHHC5 along with the nuclear transcription factor NF-Y |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
TP53 | up-regulates quantity by expression
transcriptional regulation
|
ZDHHC5 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-261150 |
|
|
Homo sapiens |
|
pmid |
sentence |
28775165 |
Mechanistic investigations revealed that mutant p53 transcriptionally upregulated ZDHHC5 along with the nuclear transcription factor NF-Y |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
ZDHHC5 | up-regulates activity
palmitoylation
|
S1PR1 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-261140 |
|
|
Homo sapiens |
SH-SY5Y Cell |
pmid |
sentence |
29185452 |
We propose that DHHC5-mediated palmitoylation of S1P1R determines Gi coupling and its signalling in a spatio/temporal manner. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |