3.0
Summary
| Name |  EZH2View Modifications |
| Full Name | Histone-lysine N-methyltransferase EZH2 |
| Synonyms | ENX-1, Enhancer of zeste homolog 2, Lysine N-methyltransferase 6 | KMT6 |
| Primary ID | Q15910 |
| Links |  -  -  |
| Type | protein |
| Relations | 29 |
| Pathways | Acute Myeloid Leukemia, ASXL1 in AML, P38 Signaling and Myogenesis, Prostate Cancer |
| Function | Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Displays a preference for substrates with less methylation, loses activity when progressively more methyl groups are incorporated into H3K27, H3K27me0 > H3K27me1 > H3K27me2 (PubMed:22323599, PubMed:30923826). Compared to EZH1-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1, CDKN2A and retinoic acid target genes. EZH2 can also methylate non-histone proteins such as the transcription factor GATA4 and the nuclear receptor RORA. Regulates the circadian clock via histone methylation at the promoter of the circadian genes. Essential for the CRY1/2-mediated repression of the transcriptional activation of PER1/2 by the CLOCK-ARNTL/BMAL1 heterodimer; involved in the di and trimethylation of 'Lys-27' of histone H3 on PER1/2 promoters which is necessary for the CRY1/2 proteins to inhibit transcription. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | USP36 | up-regulates quantity by stabilization 
deubiquitination
|
EZH2 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | AKT1 | down-regulates activity 
phosphorylation
|
EZH2 | 0.612 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | P38 Signaling and Myogenesis | |||
| + | AKT | down-regulates activity
phosphorylation
|
EZH2 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Acute Myeloid Leukemia, ASXL1 in AML, Prostate Cancer | |||
| + | MELK | up-regulates quantity by stabilization
phosphorylation
|
EZH2 | 0.333 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ATM | down-regulates quantity by destabilization
phosphorylation
|
EZH2 | 0.47 |
| Publications: | 1 | Organism: | In Vitro | |
| + | CDK1 | down-regulates
phosphorylation
|
EZH2 | 0.59 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| Pathways: | Acute Myeloid Leukemia | |||
| + | MAPK14 | down-regulates quantity by destabilization
phosphorylation
|
EZH2 | 0.379 |
| Publications: | 1 | Organism: | Mus Musculus | |
| Pathways: | P38 Signaling and Myogenesis | |||
| + | CDK2 | up-regulates activity
phosphorylation
|
EZH2 | 0.562 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | JAK2 | down-regulates
phosphorylation
|
EZH2 | 0.548 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Acute Myeloid Leukemia | |||
| + | EZH2 | down-regulates activity 
|
Skeletal_muscle_differentiation | 0.7 |
| Publications: | 1 | Organism: | Mus Musculus | |
| Pathways: | P38 Signaling and Myogenesis | |||
| + | MAPK14 | up-regulates activity
phosphorylation
|
EZH2 | 0.379 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | P38 Signaling and Myogenesis | |||
| + | EZH2 | up-regulates activity
binding
|
AR | 0.555 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Prostate Cancer | |||
| + | EZH2 | down-regulates quantity by repression
transcriptional regulation
|
HOXA10 | 0.448 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | EZH2 | down-regulates quantity by repression
transcriptional regulation
|
ALDH1A1 | 0.398 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | BTRC | down-regulates
ubiquitination
|
EZH2 | 0.385 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | EZH2 | down-regulates quantity by repression
transcriptional regulation
|
TWIST1 | 0.335 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Acute Myeloid Leukemia | |||
| + | EZH2 | form complex 
binding
|
SUZ12/EZH2 | 0.961 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PPP1R8 | up-regulates activity
binding
|
EZH2 | 0.367 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | EZH2 | down-regulates quantity by repression
transcriptional regulation
|
HOXA9 | 0.404 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Acute Myeloid Leukemia, ASXL1 in AML | |||
| + | PJA1 | down-regulates quantity by destabilization
ubiquitination
|
EZH2 | 0.501 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | EZH2 | down-regulates quantity by repression
transcriptional regulation
|
HOXB13 | 0.414 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NFIB | down-regulates quantity by repression
transcriptional regulation
|
EZH2 | 0.382 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | EZH2 | form complex
binding
|
Polycomb repressive complex 2 | 0.912 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ZDHHC5 | down-regulates activity
palmitoylation
|
EZH2 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | EZH2 | down-regulates quantity by repression
transcriptional regulation
|
SNAI2 | 0.509 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | EZH2 | down-regulates quantity by repression
transcriptional regulation
|
DACT3 | 0.253 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ERG | up-regulates quantity by expression 
transcriptional regulation
|
EZH2 | 0.351 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Prostate Cancer | |||
| + | EZH2 | down-regulates quantity by repression
transcriptional regulation
|
SSTR1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |