| + |
USP36 | up-regulates quantity by stabilization 
deubiquitination
|
EZH2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277481 |
Lys222 |
PRKFPSDkIFEAISS |
Homo sapiens |
Natural Killer Cell Line |
| pmid |
sentence |
| 31434700 |
We observed a MELK-mediated increase of EZH2 S220 phosphorylation along with a concomitant loss of EZH2 K222 ubiquitination, suggesting a phosphorylation-dependent regulation of EZH2 ubiquitination. Furthermore, we identify USP36 as the deubiquitinating enzyme that deubiquitinates EZH2 at K222. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AKT | down-regulates activity 
phosphorylation
|
EZH2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-244259 |
Ser21 |
CWRKRVKsEYMRLRQ |
Homo sapiens |
|
| pmid |
sentence |
| 16224021 |
Enhancer of zeste homolog 2 (ezh2) is a methyltransferase that plays an important role in many biological processes through its ability to trimethylate lysine 27 in histone h3. Here, we show that akt phosphorylates ezh2 at serine 21 and suppresses its methyltransferase activity by impeding ezh2 binding to histone h3 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, ASXL1 in AML, Prostate Cancer |
| + |
AKT1 | down-regulates activity
phosphorylation
|
EZH2 |
0.611 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-141043 |
Ser21 |
CWRKRVKsEYMRLRQ |
Homo sapiens |
|
| pmid |
sentence |
| 16224021 |
Enhancer of zeste homolog 2 (ezh2) is a methyltransferase that plays an important role in many biological processes through its ability to trimethylate lysine 27 in histone h3. Here, we show that akt phosphorylates ezh2 at serine 21 and suppresses its methyltransferase activity by impeding ezh2 binding to histone h3 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | P38 Signaling and Myogenesis |
| + |
MELK | up-regulates quantity by stabilization
phosphorylation
|
EZH2 |
0.334 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277480 |
Ser220 |
RPPRKFPsDKIFEAI |
Homo sapiens |
Natural Killer Cell Line |
| pmid |
sentence |
| 31434700 |
We observed a MELK-mediated increase of EZH2 S220 phosphorylation along with a concomitant loss of EZH2 K222 ubiquitination, suggesting a phosphorylation-dependent regulation of EZH2 ubiquitination. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GSK3B | down-regulates activity
phosphorylation
|
EZH2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278176 |
Ser363 |
GRLPNNSsRPSTPTI |
Homo sapiens |
|
| pmid |
sentence |
| 27494834 |
GSK3beta phosphorylates EZH2 at Ser363 and Thr367 in vitro, and activating GSK3beta upregulates Thr367 phosphorylationin vivo. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278175 |
Thr367 |
NNSSRPStPTINVLE |
Homo sapiens |
|
| pmid |
sentence |
| 27494834 |
GSK3\u03b2 phosphorylates EZH2 at Ser363 and Thr367 in vitro, and activating GSK3\u03b2 upregulates Thr367 phosphorylationin vivo. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia |
| + |
ATM | down-regulates quantity by destabilization
phosphorylation
|
EZH2 |
0.47 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276602 |
Ser729 |
LFFDYRYsQADALKY |
in vitro |
|
| pmid |
sentence |
| 24162653 |
Enhancer of zeste homolog 2 (EZH2), a core catalytic component of PRC2, is a new ATM kinase target, and ATM-mediated phosphorylation of EZH2 on Ser734 reduces protein stability. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
CDK1 | down-regulates
phosphorylation
|
EZH2 |
0.589 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-174054 |
Thr345 |
LTAERIKtPPKRPGG |
Homo sapiens |
|
| pmid |
sentence |
| 21659531 |
Cdk1, which phosphorylates ezh2 at threonines 345 and 487.Phosphorylation of thr-345 and thr-487 promotes ezh2 ubiquitination and subsequent degradation by the proteasome |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-174058 |
Thr487 |
APAEDVDtPPRKKKR |
Homo sapiens |
|
| pmid |
sentence |
| 21659531 |
Cdk1, which phosphorylates ezh2 at threonines 345 and 487.Phosphorylation of thr-345 and thr-487 promotes ezh2 ubiquitination and subsequent degradation by the proteasome |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia |
| + |
MAPK14 | down-regulates quantity by destabilization
phosphorylation
|
EZH2 |
0.38 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255663 |
Thr367 |
NNSSRPStPTINVLE |
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 28067271 |
Here, we show that p38α kinase promotes EZH2 degradation in differentiating muscle cells through phosphorylation of threonine 372 |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | P38 Signaling and Myogenesis |
| + |
CDK2 | up-regulates activity
phosphorylation
|
EZH2 |
0.561 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255656 |
Thr416 |
EANSRCQtPIKMKPN |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 23241245 |
Here, we demonstrate that the phosphorylation of EZH2 by cyclin-dependent kinases at Thr416 creates a docking site for the ForkHead-associated domain of NIPP1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
JAK3 | up-regulates activity
phosphorylation
|
EZH2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278518 |
Tyr244 |
AEELKEKyKELTEQQ |
Homo sapiens |
|
| pmid |
sentence |
| 28868240 |
These results demonstrate that phosphorylation of EZH2 by JAK3 on the Y244 increases the interaction with Polymerase II and decreases the association with PRC2 components promoting the expression of non-canonical genes.|To explore the mechanism of JAK3 mediated EZH2 activation, the authors performed co-immunoprecipitation assays, which revealed interaction of EZH2 with JAK3 and polymerase II. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
JAK2 | down-regulates
phosphorylation
|
EZH2 |
0.548 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-202711 |
Tyr641 |
KNEFISEyCGEIISQ |
Homo sapiens |
|
| pmid |
sentence |
| 24469040 |
Oncogenic y641 mutations in ezh2 prevent jak2/beta-trcp-mediated degradationbeta-trcp ubiquitinates ezh2 and jak2-mediated phosphorylation on y641 directs beta-trcp-mediated ezh2 degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia |
| + |
EZH2 | up-regulates activity
binding
|
AR |
0.554 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251542 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23239736 |
This study demonstrates that phosphorylation of EZH2 at Ser21, mediated directly or indirectly by the PI3K-Akt pathway, can switch its function from a Polycomb repressor to a transcriptional coactivator of AR (and potentially other factors). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Prostate Cancer |
| + |
EZH2 | form complex 
binding
|
Polycomb repressive complex 2 |
0.912 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-241894 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23110252 |
The PRC2 core, conserved from Drosophila to humans, is composed of four proteins that add up to about 230 kDa (Figure 1A) (see Margueron and Reinberg, 2010 for a recent review): EED (present in different isoforms), either one of the two methyltranferases Ezh1 or Ezh2 (Ezh1/2), Suz12, and either RbAp46 or RbAp48 (RbAp46/48). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | up-regulates activity
phosphorylation
|
EZH2 |
0.38 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-176548 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21902831 |
P38 can phosphorylate the histone-lysine n-methyltransferase ezh2, the catalytic subunit of the polycomb repressive complex 2 (prc2), with phosphorylation of ezh2 necessary for prc2s association with the transcriptional repressor yy1 and subsequent chromatin remodelling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | P38 Signaling and Myogenesis |
| + |
EZH2 | down-regulates quantity by repression 
transcriptional regulation
|
SNAI2 |
0.514 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254146 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23836662 |
We further demonstrated that PER2 served as a transcriptional corepressor, which recruited polycomb proteins EZH2 and SUZ12 as well as HDAC2 to octamer transcription factor 1 (OCT1) (POU2F1) binding sites of the TWIST1 and SLUG promoters to repress expression of these EMT genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NFIB | down-regulates quantity by repression
transcriptional regulation
|
EZH2 |
0.383 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-204643 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24553933 |
Nfibbinds to the ezh2 promoter and overexpression ofnfibrepresses ezh2 transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ERG | up-regulates quantity by expression 
transcriptional regulation
|
EZH2 |
0.35 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251555 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25277175 |
Increased expression of ERG or other ETS factors under control of androgen responsive promoter (TMPRSS2) is an inevitable consequence of the fusion events, and it activates transcriptional program that contributes to oncogenesis by upregulating expression of, among others, MYC, EZH2 and SOX9 and repressing NKX3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Prostate Cancer |
| + |
EZH2 | down-regulates quantity by repression
transcriptional regulation
|
DACT3 |
0.254 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254142 |
|
|
Homo sapiens |
Epithelial Ovarian Cancer Cell |
| pmid |
sentence |
| 22144423 |
For three selected genes (ALDH1A1, SSTR1, and DACT3), we validated their upregulation upon EZH2 knockdown and confirmed the binding of EZH2/H3K27Me3 to their genomic loci. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EZH2 | down-regulates quantity by repression
transcriptional regulation
|
SSTR1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254143 |
|
|
Homo sapiens |
Epithelial Ovarian Cancer Cell |
| pmid |
sentence |
| 22144423 |
For three selected genes (ALDH1A1, SSTR1, and DACT3), we validated their upregulation upon EZH2 knockdown and confirmed the binding of EZH2/H3K27Me3 to their genomic loci. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EZH2 | down-regulates activity
|
Skeletal_muscle_differentiation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255719 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 15520282 |
We report that Ezh2 expression was developmentally regulated in the myotome compartment of mouse somites and that its down-regulation coincided with activation of muscle gene expression and differentiation of satellite-cell-derived myoblasts |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | P38 Signaling and Myogenesis |
| + |
EZH2 | down-regulates quantity by repression
transcriptional regulation
|
HOXA10 |
0.447 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260070 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20565746 |
These data support the proposed regulatory impact of particular PRC2-proteins in expression of HOXA9 and HOXA10 in NK/T-cells. In mammalian cells knockdown of PRC2 components EZH2 or PHF1 led to upregulated HOXA gene expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BTRC | down-regulates
ubiquitination
|
EZH2 |
0.382 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-204481 |
|
|
Homo sapiens |
Lymphoma Cell |
| pmid |
sentence |
| 24469040 |
_-trcp ubiquitinates ezh2 and jak2-mediated phosphorylation on y641 directs _-trcp-mediated ezh2 degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EZH2 | down-regulates quantity by repression
transcriptional regulation
|
ALDH1A1 |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254141 |
|
|
Homo sapiens |
Epithelial Ovarian Cancer Cell |
| pmid |
sentence |
| 22144423 |
For three selected genes (ALDH1A1, SSTR1, and DACT3), we validated their upregulation upon EZH2 knockdown and confirmed the binding of EZH2/H3K27Me3 to their genomic loci. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EZH2 | form complex
binding
|
SUZ12/EZH2 |
0.961 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-146758 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16712789 |
Suz12 is a polycomb group protein that forms polycomb repressive complexes (prc2/3) together with eed and histone methyltransferase ezh2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPP1R8 | up-regulates activity
binding
|
EZH2 |
0.366 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255665 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23241245 |
Recruited NIPP1 enables the net phosphorylation of EZH2 by inhibiting its dephosphorylation by PP1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EZH2 | down-regulates quantity by repression
transcriptional regulation
|
HOXA9 |
0.405 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260068 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20565746 |
These data support the proposed regulatory impact of particular PRC2-proteins in expression of HOXA9 and HOXA10 in NK/T-cells. In mammalian cells knockdown of PRC2 components EZH2 or PHF1 led to upregulated HOXA gene expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, ASXL1 in AML |
| + |
PJA1 | down-regulates quantity by destabilization
ubiquitination
|
EZH2 |
0.499 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255664 |
|
|
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 28067271 |
Biochemical and genetic evidence demonstrates that the MYOD-induced E3 ubiquitin ligase Praja1 (PJA1) is involved in regulating EZH2 levels upon p38α activation. EZH2 premature degradation in proliferating myoblasts is prevented by low levels of PJA1, its cytoplasmic localization and the lower activity towards unphosphorylated EZH2 |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
EZH2 | down-regulates quantity by repression
transcriptional regulation
|
HOXB13 |
0.414 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254144 |
|
|
Homo sapiens |
Prostate Cancer Cell Line |
| pmid |
sentence |
| 22808286 |
EZH2 recruited DNMT3b to HOXB13 promoter to form a repression complex. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ZDHHC5 | down-regulates activity
palmitoylation
|
EZH2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261144 |
|
|
Homo sapiens |
Glioma Cell |
| pmid |
sentence |
| 28775165 |
Mechanistic investigations revealed that mutant p53 transcriptionally upregulated ZDHHC5 along with the nuclear transcription factor NF-Y. These events contributed to the development of glioma by promoting the self-renewal capacity and tumorigenicity of glioma stem-like cells, by altering the palmitoylation and phosphorylation status of the tumor suppressor EZH2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EZH2 | down-regulates quantity by repression
transcriptional regulation
|
TWIST1 |
0.336 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254151 |
|
|
Homo sapiens |
MCF-10A Cell |
| pmid |
sentence |
| 23836662 |
We further demonstrated that PER2 served as a transcriptional corepressor, which recruited polycomb proteins EZH2 and SUZ12 as well as HDAC2 to octamer transcription factor 1 (OCT1) (POU2F1) binding sites of the TWIST1 and SLUG promoters to repress expression of these EMT genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia |
3.0
EZH2
- 
- 