+ |
ABL1 |
phosphorylation
|
SRCIN1 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-200854 |
Tyr264 |
IYRKEPLyAAFPGSH |
Homo sapiens |
|
pmid |
sentence |
23383002 |
Furthermore, we identify abl as the major tyrosine kinase that can trigger p140cap phosphorylation on these sequences. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-200858 |
Tyr396 |
LVKGEGLyADPYGLL |
Homo sapiens |
|
pmid |
sentence |
23383002 |
Mapping of p140cap phosphorylation sites: the eplya and eglya motifs have a key role in tyrosine phosphorylation and csk binding, and are substrates of the abl kinase |
|
Publications: |
2 |
Organism: |
Homo Sapiens |
Tissue: |
Brain |
+ |
SRC | up-regulates activity
phosphorylation
|
SRCIN1 |
0.51 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-263196 |
|
|
Homo sapiens |
HEK-293 Cell |
pmid |
sentence |
8647432 |
Phosphorylation of multiple tyrosine-containing motifs found on Sin correlated with c-Crk and cellular phosphoprotein binding to Sin as well as increased c-Src activity. These data suggest that (1) SH2 and SH3 ligand sites on Sin cooperatively activate the signaling potential of c-Src, (2) Sin acts as both an activator and a substrate for c-Src, and (3) phosphorylated Sin may serve as a signaling effector molecule for Src by binding to multiple cellular proteins. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |