4.0
Summary
| Name |  BCL11B
|
| Full Name | B-cell lymphoma/leukemia 11B |
| Synonyms | BCL-11B, B-cell CLL/lymphoma 11B, COUP-TF-interacting protein 2, Radiation-induced tumor suppressor gene 1 protein, hRit1 | CTIP2, RIT1 |
| Primary ID | Q9C0K0 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (PubMed:27959755). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes (PubMed:16809611). Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). May also function in the P53-signaling pathway (By similarity). |
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transcriptional regulation
transcriptional regulation