Relation Results

Summary

Name SATB2
Full Name DNA-binding protein SATB2
Synonyms Special AT-rich sequence-binding protein 2 | KIAA1034
Primary ID Q9UPW6
Links - -
Type protein
Relations 9
Function Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcript ...
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Type: Score: Layout: SPV 
0.5710.20.2610.3380.2980.3760.5050.2PIAS1SATB2IGHMSMAD5UPF3BNR4A2TP63BCL11BSMAD1

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ PIAS1down-regulates activity img/direct_inhibition.png sumoylation SATB2 0.571
Identifier Residue Sequence Organism Cell Line
SIGNOR-268932 Lys233 YKKYKKIkVERVERE Homo sapiens
pmid sentence
We found that SATB2 differs from the closely related thymocyte-specific protein SATB1 by modifications of two lysines with the small ubiquitive related modifier (SUMO), which are augmented specifically by the SUMO E3 ligase PIAS1.
Identifier Residue Sequence Organism Cell Line
SIGNOR-269112 Lys350 PPIPRAVkPEPTNSS Homo sapiens HEK-293 Cell
pmid sentence
We found that SATB2 differs from the closely related thymocyte-specific protein SATB1 by modifications of two lysines with the small ubiquitive related modifier (SUMO), which are augmented specifically by the SUMO E3 ligase PIAS1.
Publications: 2 Organism: Homo Sapiens
+ SATB2up-regulates quantity img/direct-activation.png transcriptional regulation IGHM 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268933 Homo sapiens
pmid sentence
The SATB2 protein was shown to bind MAR sequences flanking the enhancer of the endogenous immunoglobulin μ heavy chain (IgH) gene in vivo, and this binding was found to correlate with an increase in the expression of a transfected rearranged μ wild-type gene
Publications: 1 Organism: Homo Sapiens
+ SMAD5up-regulates quantity img/direct-activation.png transcriptional regulation SATB2 0.261
Identifier Residue Sequence Organism Cell Line
SIGNOR-268939 Mus musculus
pmid sentence
Chromatin immunoprecipitation (ChIP) revealed a subset of the BIG (BMP4 induced genes) signature, including Satb2, Smad6, Hand1, Gadd45γ and Gata3, that was bound by Smad1/5 in the developing mandible, revealing direct Smad-mediated regulation
Publications: 1 Organism: Mus Musculus
+ SATB2up-regulates quantity by expression img/indirect-activation.png transcriptional regulation UPF3B 0.338
Identifier Residue Sequence Organism Cell Line
SIGNOR-255137 Homo sapiens HEK-293 Cell
pmid sentence
chromatin immunoprecipitation demonstrates that SATB2 binds to the UPF3B promoter, and a luciferase reporter assay confirmed that SATB2 expression significantly activates gene transcription using the UPF3B promoter.
Publications: 1 Organism: Homo Sapiens
+ SATB2down-regulates quantity img/direct_inhibition.png transcriptional regulation NR4A2 0.298
Identifier Residue Sequence Organism Cell Line
SIGNOR-268930 Homo sapiens
pmid sentence
Satb2 represses the transcription of Nr4a2. The misexpression of Nr4a2 together with Ctip2 induces expression of SubC-specific genes in wild-type Rsp, and simultaneous knockdown of these two genes in Rsp Satb2-mutant cells prevents their fate transition to SubC identity. Thus, Satb2 serves as a determinant gene in the Rsp regionalization by repressing Nr4a2 and Ctip2 during cortical development
Publications: 1 Organism: Homo Sapiens
+ SATB2down-regulates activity img/direct_inhibition.png binding TP63 0.376
Identifier Residue Sequence Organism Cell Line
SIGNOR-255149 Homo sapiens
pmid sentence
SATB2 attenuates p63-mediated gene expression of perp (p53 apoptosis effector related to PMP-22), a critical downstream target gene during development, and specifically decreases p63 perp promoter binding.
Publications: 1 Organism: Homo Sapiens
+ SATB2down-regulates quantity img/direct_inhibition.png transcriptional regulation BCL11B 0.505
Identifier Residue Sequence Organism Cell Line
SIGNOR-268931 Homo sapiens
pmid sentence
Satb2 represses the transcription of Nr4a2. The misexpression of Nr4a2 together with Ctip2 induces expression of SubC-specific genes in wild-type Rsp, and simultaneous knockdown of these two genes in Rsp Satb2-mutant cells prevents their fate transition to SubC identity. Thus, Satb2 serves as a determinant gene in the Rsp regionalization by repressing Nr4a2 and Ctip2 during cortical development
Publications: 1 Organism: Homo Sapiens
+ SMAD1up-regulates quantity img/direct-activation.png transcriptional regulation SATB2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268934 Mus musculus
pmid sentence
Chromatin immunoprecipitation (ChIP) revealed a subset of the BIG (BMP4 induced genes) signature, including Satb2, Smad6, Hand1, Gadd45γ and Gata3, that was bound by Smad1/5 in the developing mandible, revealing direct Smad-mediated regulation
Publications: 1 Organism: Mus Musculus
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