Summary

Name MCOLN1
Full Name Mucolipin-1
Synonyms MG-2, Mucolipidin | ML4
Primary ID Q9GZU1
Links - -
Type protein
Relations 6
Pathways Macropinocytosis
Function Nonselective cation channel probably playing a role in the regulation of membrane trafficking events and of metal homeostasis. Proposed to play a major role in Ca(2+) release from late endosome and lysosome vesicles to the cytoplasm, which is important for many lysosome-dependent cellular events, including the fusion and trafficking of these organelles, exocytosis and autophagy (PubMed:11013137, PubMed:12459486, PubMed:15336987, PubMed:14749347, PubMed:29019983, PubMed:27623384). Required for efficient uptake of large particles in macrophages in which Ca(2+) release from the lysosomes triggers lysosomal exocytosis. May also play a role in phagosome-lysosome fusion (By similarity). Involved in lactosylceramide trafficking indicative for a role in the regulation of late endocytic membrane fusion/fission events (PubMed:16978393). By mediating lysosomal Ca(2+) release is involved in regulation of mTORC1 signaling and in mTOR/TFEB-dependent lysosomal adaptation to environmental cues such as nutrient levels (PubMed:27787197, PubMed:25733853). Seems to act as lysosomal active oxygen species (ROS) sensor involved in ROS-induced TFEB activation and autophagy (PubMed:27357649). Functions as a Fe(2+) permeable channel in late endosomes and lysosomes (PubMed:18794901). Proposed to play a role in zinc homeostasis probably implicating its association with TMEM163 (PubMed:25130899) In adaptive immunity, TRPML2 and TRPML1 may play redundant roles in the function of the specialized lysosomes of B cells (By similarity).

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ PRKACAdown-regulates img/direct_inhibition.png phosphorylation MCOLN1 0.2
Publications: 2 Organism: Homo Sapiens
+ TFE3up-regulates quantity by expression img/indirect-activation.png transcriptional regulation MCOLN1 0.339
Publications: 1
+ MCOLN1up-regulates img/indirect-activation.png Lysosome fusion 0.7
Publications: 1 Organism: Homo Sapiens
+ FIG4up-regulates activity img/indirect-activation.png MCOLN1 0.356
Publications: 1 Organism: Homo Sapiens
+ MCOLN1up-regulates quantity img/direct-activation.png relocalization calcium(2+) 0.8
Publications: 1 Organism: Homo Sapiens