| + |
SIK2 | up-regulates activity 
phosphorylation
|
LRP6 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275399 |
Ser1490 |
AILNPPPsPATERSH |
Homo sapiens |
Breast Cancer Stem Cell |
| pmid |
sentence |
| 35277657 |
Mechanistically, SIK2, phosphorylated by CK1α, directly phosphorylated LRP6 in a SIK2 kinase activity-dependent manner, leading to Wnt/β-catenin signaling pathway activation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275404 |
Ser1490 |
AILNPPPsPATERSH |
Homo sapiens |
Breast Cancer Stem Cell |
| pmid |
sentence |
| 35277657 |
Mechanistically, SIK2, phosphorylated by CK1α, directly phosphorylated LRP6 in a SIK2 kinase activity-dependent manner, leading to Wnt/β-catenin signaling pathway activation. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
SIK2 | up-regulates activity
phosphorylation
|
PIK3R1 |
0.327 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277269 |
Ser154 |
STLYRTQsSSNLAEL |
in vitro |
|
| pmid |
sentence |
| 27478041 |
The Regulatory Subunit of PI3K Is a Direct Catalytic Target of SIK2. These data confirm that p85α is a direct catalytic substrate of SIK2 and that SIK2 S154 phosphorylation significantly increases the activity of the PI3K/AKT pathway in ovarian cancer cells. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
SIK2 | down-regulates 
phosphorylation
|
CRTC2 |
0.734 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-166372 |
Ser171 |
SALNRTSsDSALHTS |
Homo sapiens |
|
| pmid |
sentence |
| 20577053 |
Phosphorylation on the ser171 residue of crtc2 by ampk and ampk-related kinases, including the salt-inducible kinases (siks), is critical for determining the activity, cellular localization, and degradation of crtc2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-142218 |
Ser171 |
SALNRTSsDSALHTS |
Homo sapiens |
|
| pmid |
sentence |
| 16308421 |
Phosphorylation on the ser171 residue of crtc2 by ampk and ampk-related kinases, including the salt-inducible kinases (siks), is critical for determining the activity, cellular localization, and degradation of crtc2 |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
SIK2 | down-regulates
phosphorylation
|
CEP250 |
0.326 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-167488 |
Ser2392 |
AGLHHSLsHSLLAVA |
Homo sapiens |
|
| pmid |
sentence |
| 20708153 |
Here, we show that the salt inducible kinase 2 (sik2) localizes at the centrosome, plays a key role in the initiation of mitosis, and regulates the localization of the centrosome linker protein, c-nap1, through s2392 phosphorylation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SIK2 |
phosphorylation
|
CEP250 |
0.326 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-167492 |
Ser2394 |
LHHSLSHsLLAVAQA |
Homo sapiens |
|
| pmid |
sentence |
| 20708153 |
Remarkably, lc-ms confirmed that the predominant serine phosphorylation site of the recombinant carboxy-terminal domain of c-nap1 is s2392 at the predicted consensus phosphorylation sequence and to a lesser extent s2394. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SIK2 | up-regulates activity
phosphorylation
|
SIK2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277268 |
Ser343 |
RLKSHRSsFPVEQRL |
in vitro |
|
| pmid |
sentence |
| 27478041 |
SIK2 S358 Autophosphorylation Is a Marker of SIK2 Activity |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
SIK2 |
phosphorylation
|
IRS1 |
0.586 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-99059 |
Ser794 |
QHLRLSTsSGRLLYA |
Homo sapiens |
|
| pmid |
sentence |
| 12624099 |
Sik2 could phosphorylate ser(794) of human irs-1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-99055 |
Ser794 |
QHLRLSTsSGRLLYA |
Homo sapiens |
|
| pmid |
sentence |
| 12624099 |
These results suggest that highly expressed sik2 in insulin-stimulated adipocytes phosphorylates ser794_ of irs-1 and, as a result, might modulate the efficiency ofinsulinsignal transduction |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
SIK2 | down-regulates quantity
phosphorylation
|
IRS1 |
0.586 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265745 |
Ser794 |
QHLRLSTsSGRLLYA |
|
|
| pmid |
sentence |
| 24841198 |
SIK2 is known to attenuate insulin signaling by phosphorylating IRS-1/Ser789 |
|
| Publications: |
1 |
| + |
SIK2 | down-regulates
phosphorylation
|
CDK5R1 |
0.337 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-204648 |
Ser91 |
ENLKKSLsCANLSTF |
Homo sapiens |
|
| pmid |
sentence |
| 24561619 |
Sik2 phosphorylates p35 at ser 91, to trigger its ubiquitylation by pja2 and promote insulin secretion. _-cell knockout of sik2 leads to accumulation of p35 and impaired secretion |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STK11 | up-regulates
phosphorylation
|
SIK2 |
0.458 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-122788 |
Thr175 |
KSGELLAtWCGSPPY |
Homo sapiens |
|
| pmid |
sentence |
| 14976552 |
A total of 12 human kinases (nuak1, nuak2, brsk1, brsk2, qik, qsk, sik, mark1, mark2, mark3, mark4 and melk) are related to ampk. Here we demonstrate that lkb1 can phosphorylate the t-loop of all the members of this subfamily, apart from melk, increasing their activity >50-fold. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SIK2 | down-regulates 
|
MLXIPL |
0.33 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265746 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 24841198 |
Moreover, SIK2 was shown to down-regulate the carbohydrate-responsive element-binding protein (ChREBP)-mediated lipogenesis in hepatocytes through the inhibitory phosphorylation of p300/Ser89 and to prevent steatosis in mice |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
3.0
SIK2
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