Summary

Name PIK3R1
Full Name Phosphatidylinositol 3-kinase regulatory subunit alpha
Synonyms PI3-kinase regulatory subunit alpha, PI3K regulatory subunit alpha, PtdIns-3-kinase regulatory subunit alpha, Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha, PI3-kinase subunit p85-alpha, PtdIns-3-kinase regulatory subunit p85-alpha | GRB1
Primary ID P27986
Links - -
Type protein
Relations 38
Pathways Glioblastoma Multiforme, MTOR Signaling
Inhibitors LY294002
Function Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed:17626883, PubMed:19805105, PubMed:7518429). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348923).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png dephosphorylation PIK3R1 0.329
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation PIK3R1 0.653
Publications: 3 Organism: Chlorocebus Aethiops
Pathways:MTOR Signaling
+ down-regulates activity img/direct_inhibition.png phosphorylation PIK3R1 0.603
Publications: 1 Organism: Chlorocebus Aethiops
Pathways:T cell activation
+ up-regulates activity img/direct-activation.png binding PIK3CG 0.711
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates activity img/direct-activation.png binding PIK3R1 0.562
Publications: 2 Organism: Mus Musculus
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination PIK3R1 0.489
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition PIK3R1 0.8
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ up-regulates img/direct-activation.png binding PIK3R1 0.531
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PIK3R1 0.39
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PIK3R1 0.418
Publications: 1 Organism: Homo Sapiens
Pathways:T cell activation
+ up-regulates activity img/direct-activation.png binding PIK3R1 0.806
Publications: 1 Organism: Rattus Norvegicus
Tissue: Skeletal Muscle
Pathways:MTOR Signaling, IGF and Myogenesis
+ up-regulates activity img/direct-activation.png binding PIK3CD 0.82
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates activity img/direct-activation.png binding PIK3R1 0.46
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PIK3CA 0.934
Publications: 1 Organism: Chlorocebus Aethiops
Pathways:Glioblastoma Multiforme, MTOR Signaling, IGF and Myogenesis
+ up-regulates img/direct-activation.png binding PIK3R1 0.799
Publications: 2 Organism: Homo Sapiens
Tissue: Breast Cancer Cell
Pathways:Glioblastoma Multiforme
+ up-regulates activity img/direct-activation.png binding PIK3R1 0.472
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PIK3R1 0.412
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png binding PIK3R1 0.607
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png ubiquitination PIK3R1 0.674
Publications: 1 Organism: Homo Sapiens
Pathways:Glioblastoma Multiforme
+ form complex img/form-complex.png binding PI3K 0.934
Publications: 1 Organism: Homo Sapiens
Pathways:T cell activation
+ up-regulates quantity img/indirect-activation.png PIP3 0.8
Publications: 1 Organism: Rattus Norvegicus
Pathways:Glioblastoma Multiforme, MTOR Signaling, T cell activation
+ up-regulates activity img/indirect-activation.png PIK3R1 0.543
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding PIK3R1 0.479
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding PIK3R1 0.285
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PIK3R1 0.262
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PIK3CB 0.844
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates img/direct-activation.png binding PIK3R1 0.46
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PIK3R1 0.512
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates activity img/direct-activation.png binding PIK3R1 0.714
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates img/direct-activation.png binding PIK3R1 0.609
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation PIK3R1 0.265
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PIK3R1 0.538
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PIK3R1 0.704
Publications: 1 Organism: Homo Sapiens
Pathways:IGF and Myogenesis
+ up-regulates img/direct-activation.png binding PIK3R1 0.302
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle, Myotube