3.0
Summary
| Name |  MED28View Modifications |
| Full Name | Mediator of RNA polymerase II transcription subunit 28 |
| Synonyms | Endothelial-derived protein 1, Mediator complex subunit 28, Merlin and Grb2-interacting cytoskeletal protein, Magicin, Tumor angiogenesis marker EG-1 | EG1 |
| Primary ID | Q9H204 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May be part of a complex containing NF2/merlin that participates in cellular signaling to the actin cytoskeleton downstream of tyrosine kinase signaling pathways. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | FYN | up-regulates 
phosphorylation
|
MED28 | 0.457 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | LCK | up-regulates
phosphorylation
|
MED28 | 0.451 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MED28 | form complex 
binding
|
Core mediator complex | 0.832 |
| Publications: | 1 | Organism: | Homo Sapiens | |