| + |
HES1 | down-regulates quantity by repression 
transcriptional regulation
|
NEUROG2 |
0.325 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265142 |
|
|
Mus musculus |
Neuron |
| pmid |
sentence |
| 30030829 |
The basic-helixloop-helix factors HES1 and HES5 repress the expression of the proneural genes (Ascl1, Atoh1, Neurog1 and Neurog2) and thereby inhibit NSCs differentiation and neuron production |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Retinoic acid Signaling |
| + |
NEUROG2 | up-regulates 
|
Neurogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265173 |
|
|
Mus musculus |
Neuron |
| pmid |
sentence |
| 18400164 |
While the mechanisms by which Ngn2 promotes neurogenesis have been characterized, little is known about how Ngn2 confers neuronal cell-type identity during spinal cord development. Ngn1 and Ngn2, two mammalian orthologs of the Drosophila proneural bHLH gene atonal, are expressed in overlapping patterns throughout the developing nervous system and act as important regulators of developmental neurogenesis |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Tissue: |
Brain |
| Pathways: | Retinoic acid Signaling |
| + |
NEUROG3 | down-regulates quantity by repression
transcriptional regulation
|
NEUROG2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254633 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19028584 |
Ngn3 overexpression altered the expression of a number of regulatory genes, including ash1, ath3, ath5, chx10, neuroD, ngn1, ngn2, and NSCL1. Early gene ngn1 was induced, but ash1, ngn2, ath3, and chx10, whose expressions persist through later phases of neurogenesis, were down-regulated. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HES5 | down-regulates quantity by repression
transcriptional regulation
|
NEUROG2 |
0.421 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-265143 |
|
|
Mus musculus |
Neuron |
| pmid |
sentence |
| 30030829 |
The basic-helixloop-helix factors HES1 and HES5 repress the expression of the proneural genes (Ascl1, Atoh1, Neurog1 and Neurog2) and thereby inhibit NSCs differentiation and neuron production |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
3.0
NEUROG2
- 
- 