Summary

Name SMDT1
Full Name Essential MCU regulator, mitochondrial
Synonyms Single-pass membrane protein with aspartate-rich tail 1, mitochondrial | C22orf32, EMRE
Primary ID Q9H4I9
Links - -
Type protein
Relations 4
Function Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria (PubMed:24231807, PubMed:26774479, PubMed:27099988). Required to bridge the calcium-sensing proteins MICU1 and MICU2 with the calcium-conducting subunit MCU (PubMed:24231807). Plays a central role in regulating the uniplex complex response to intracellular calcium signaling (PubMed:27099988). Acts by mediating activation of MCU and retention of MICU1 to the MCU pore, in order to ensure tight regulation of the uniplex complex and appropriate responses to intracellular calcium signaling (PubMed:27099988).

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Relations

Regulator Mechanism target score ℹ
+ SMDT1form complex img/form-complex.png binding MCU_MICUB_variant 0.619
Publications: 1 Organism: Homo Sapiens
+ SMDT1form complex img/form-complex.png binding MCU_MICU2_variant 0.619
Publications: 1 Organism: Homo Sapiens
+ SMDT1form complex img/form-complex.png binding MCU_MICU3_variant 0.614
Publications: 1 Organism: Homo Sapiens
+ SMDT1form complex img/form-complex.png binding MCU_MICU1_variant 0.622
Publications: 1 Organism: Homo Sapiens