Summary

Name TUT1
Full Name Speckle targeted PIP5K1A-regulated poly(A) polymerase
Synonyms Star-PAP, EC 2.7.7.19, RNA-binding motif protein 21, RNA-binding protein 21, U6 snRNA-specific terminal uridylyltransferase 1, U6-TUTase, EC 2.7.7.52 | RBM21
Primary ID Q9H6E5
Links - -
Type protein
Relations 4
Function Poly(A) polymerase that creates the 3'-poly(A) tail of specific pre-mRNAs (PubMed:18288197, PubMed:21102410). Localizes to nuclear speckles together with PIP5K1A and mediates polyadenylation of a select set of mRNAs, such as HMOX1 (PubMed:18288197). In addition to polyadenylation, it is also required for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3'UTR of pre-mRNAs (PubMed:21102410). In addition to adenylyltransferase activity, also has uridylyltransferase activity (PubMed:16790842, PubMed:18288197, PubMed:28589955). However, the ATP ratio is higher than UTP in cells, suggesting that it functions primarily as a poly(A) polymerase (PubMed:18288197). Acts as a specific terminal uridylyltransferase for U6 snRNA in vitro: responsible for a controlled elongation reaction that results in the restoration of the four 3'-terminal UMP-residues found in newly transcribed U6 snRNA (PubMed:16790842, PubMed:18288197, PubMed:28589955). Not involved in replication-dependent histone mRNA degradation. {ECO:0000269|PubMed:16790842, ECO:0000269|PubMed:18288197, ECO:0000269|PubMed:21102410, ECO:0000269|PubMed:28589955}.

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ CSNK1A1up-regulates activity img/direct-activation.png phosphorylation TUT1 0.271
Publications: 1 Organism: Homo Sapiens
+ KLHL7down-regulates quantity by destabilization img/direct_inhibition.png binding TUT1 0.2
Publications: 1 Organism: Homo Sapiens
+ Cullin 3-RBX1-Skp1down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination TUT1 0.2
Publications: 1 Organism: Homo Sapiens
+ TUT1up-regulates img/indirect-activation.png mRNA_polyadenylation 0.7
Publications: 1 Organism: Homo Sapiens