3.0
Summary
| Name |  PLEKHG2View Modifications |
| Full Name | Pleckstrin homology domain-containing family G member 2 |
| Synonyms | PH domain-containing family G member 2 | |
| Primary ID | Q9H7P9 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein) (PubMed:18045877). Involved in the regulation of actin polymerization (PubMed:26573021). {ECO:0000250|UniProtKB:Q6KAU7, ECO:0000269|PubMed:18045877, ECO:0000269|PubMed:26573021}. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | SRC | up-regulates activity 
phosphorylation
|
PLEKHG2 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SRC |
phosphorylation
|
PLEKHG2 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PLEKHG2 | up-regulates activity
binding
|
PIK3R3 | 0.253 |
| Publications: | 1 | Organism: | Homo Sapiens | |