Relation Results

Summary

Name PLEKHG2
Full Name Pleckstrin homology domain-containing family G member 2
Synonyms PH domain-containing family G member 2 |
Primary ID Q9H7P9
Links - -
Type protein
Relations 3
Function May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. ...
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Type: Score: Layout: SPV 
0.20.25SRCPLEKHG2PIK3R3

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ SRC img/unknown.png phosphorylation PLEKHG2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-273537 Tyr489 SEPVKDPyVMFPQNA Homo sapiens HEK-293 Cell
pmid sentence
Through deletion and base substitution mutagenesis we have identified Tyr489 of PLEKHG2 as the site phosphorylated by cSrc.Furthermore, PLEKHG2 is tyrosine phosphorylated at Tyr489 by ephrinB2 receptor signaling via cSrc. Investigation of the physiological function of tyrosine phosphorylation at Tyr489 in PLEKHG2 remains a subject for future studies.
Publications: 1 Organism: Homo Sapiens
+ SRCup-regulates activity img/direct-activation.png phosphorylation PLEKHG2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-273808 Tyr489 SEPVKDPyVMFPQNA Homo sapiens HEK-293 Cell
pmid sentence
Through deletion and base substitution mutagenesis we have identified Tyr489 of PLEKHG2 as the site phosphorylated by cSrc.The interaction between PLEKHG2 and the full-length of PIK3R3, but not ABL1, occurs in a tyrosine-phosphorylation-dependent manner.
Publications: 1 Organism: Homo Sapiens
+ PLEKHG2up-regulates activity img/direct-activation.png binding PIK3R3 0.25
Identifier Residue Sequence Organism Cell Line
SIGNOR-273809 Homo sapiens HEK-293 Cell
pmid sentence
Through deletion and base substitution mutagenesis we have identified Tyr489 of PLEKHG2 as the site phosphorylated by cSrc.The interaction between PLEKHG2 and the full-length of PIK3R3, but not ABL1, occurs in a tyrosine-phosphorylation-dependent manner.
Publications: 1 Organism: Homo Sapiens
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