Summary

Name UCK1
Full Name Uridine-cytidine kinase 1
Synonyms UCK 1, EC 2.7.1.48, Cytidine monophosphokinase 1, Uridine monophosphokinase 1 | URK1
Primary ID Q9HA47
Links - -
Type protein
Relations 11
Pathways Nucleotode Salvage
Function Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate (PubMed:11306702). Does not phosphorylate deoxyribonucleosides or purine ribonucleosides (PubMed:11306702). Can use ATP or GTP as a phosphate donor (PubMed:11306702). Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine (PubMed:11306702). {ECO:0000269|PubMed:11306702}.

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ USP28up-regulates quantity by stabilization img/direct-activation.png deubiquitination UCK1 0.2
Publications: 1
+ KLHL2down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination UCK1 0.346
Publications: 1
+ UCK1down-regulates quantity img/direct_inhibition.png chemical modification ATP(4-)
Publications: 1 Organism: Homo Sapiens
+ UCK1up-regulates quantity img/direct-activation.png chemical modification ADP(3-)
Publications: 1 Organism: Homo Sapiens
+ UCK1down-regulates quantity img/direct_inhibition.png chemical modification cytidine
Publications: 1 Organism: Homo Sapiens
+ UCK1up-regulates quantity img/direct-activation.png chemical modification cytidine 5'-monophosphate(2-) 0.8
Publications: 2 Organism: , Homo Sapiens
+ UCK1down-regulates quantity img/direct_inhibition.png chemical modification uridine
Publications: 1 Organism: Homo Sapiens
+ UCK1up-regulates quantity img/direct-activation.png chemical modification uridine 5'-monophosphate(2-)
Publications: 2 Organism: Homo Sapiens,
+ ATMdown-regulates quantity by destabilization img/direct_inhibition.png phosphorylation UCK1 0.2
Publications: 1