3.0
Summary
| Name |  UCK1View Modifications |
| Full Name | Uridine-cytidine kinase 1 |
| Synonyms | UCK 1, EC 2.7.1.48, Cytidine monophosphokinase 1, Uridine monophosphokinase 1 | URK1 |
| Primary ID | Q9HA47 |
| Links |  -  -  |
| Type | protein |
| Relations | 5 |
| Function | Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate (PubMed:11306702). Does not phosphorylate deoxyribonucleosides or purine ribonucleosides (PubMed:11306702). Can use ATP or GTP as a phosphate donor (PubMed:11306702). Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine (PubMed:11306702). {ECO:0000269|PubMed:11306702}. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | KLHL2 | down-regulates quantity by destabilization 
ubiquitination
|
UCK1 | 0.35 |
| Publications: | 1 | |||
| + | USP28 | up-regulates quantity by stabilization 
deubiquitination
|
UCK1 | 0.2 |
| Publications: | 1 | |||
| + | ATM | down-regulates quantity by destabilization
phosphorylation
|
UCK1 | 0.2 |
| Publications: | 1 | |||
| + | UCK1 | up-regulates quantity
chemical modification
|
uridine 5'-monophosphate(2-) | 0.8 |
| Publications: | 1 | |||
| + | UCK1 | up-regulates quantity
chemical modification
|
cytidine 5'-monophosphate(2-) | 0.8 |
| Publications: | 1 | |||