Summary

Name UPF2
Full Name Regulator of nonsense transcripts 2
Synonyms Nonsense mRNA reducing factor 2, Up-frameshift suppressor 2 homolog, hUpf2 | KIAA1408, RENT2
Primary ID Q9HAU5
Links - -
Type protein
Relations 3
Function Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC). Recruited by UPF3B associated with the EJC core at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF3B stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA.

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png binding UPF1 0.979
Publications: 1 Organism: In Vitro
+ form complex img/form-complex.png binding Upf-EJC 0.972
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Synaptic_plasticity 0.7
Publications: 1 Organism: Homo Sapiens
Tissue: Brain