Relation Results

Summary

Name Synaptic_plasticity
Primary ID SIGNOR-PH158
Type phenotype
Description A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers GO:0048167
Relations 23
Pathways Dopaminergic Synapse, Glutamatergic synapse, GABAergic synapse , Oxytocin signaling, Rett syndrome

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Type: Score: Layout: SPV 
0.70.70.70.70.70.70.70.70.70.70.70.70.70.70.70.70.70.70.70.70.7ARHGEF9Synaptic_plasticityLRFN4DSCAML1BDNFFKBP5DLG4AMPALRFN5KIRREL3DSCAMPKAGPHNPTPRFNLGN2GRIA2CREB1PTPRDPTPRSRELNUPF2calcium(2+)

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Relations
Regulator
Mechanism
target
score ℹ
+ ARHGEF9up-regulates img/indirect-activation.png Synaptic_plasticity 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-264976 Homo sapiens Neuron
pmid sentence
Gephyrin is believed to act as a scaffold at inhibitory synapses, in a manner analogous to that of the prototypic excitatory synaptic scaffold, PSD-95. The best-known function of gephyrin is to bring the inhibitory synaptic receptors and to stabilize them at the inhibitory synapses. gephyrin interacts with NL-2 and collybistin, suggesting that it may be critical for the maturation or maintenance of inhibitory synapses.
Publications: 1 Organism: Homo Sapiens
Pathways:GABAergic synapse
+ LRFN4up-regulates img/indirect-activation.png Synaptic_plasticity 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-264092 Homo sapiens Neuron
pmid sentence
The SALM (synaptic adhesion-like molecule) family of adhesion molecules, also known as Lrfn, belongs to the superfamily of leucine-rich repeat (LRR)-containing adhesion molecules. Proteins of the SALM family, which includes five known members (SALMs 1-5), have been implicated in the regulation of neurite outgrowth and branching, and synapse formation and maturation.SALM3 and SALM5, but not other SALMs, possess synaptogenic activity, inducing presynaptic differentiation in contacting axons.
Publications: 1 Organism: Homo Sapiens
+ DSCAML1down-regulates img/indirect_inhibition.png Synaptic_plasticity 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-264281 Homo sapiens
pmid sentence
The DSCAM/L1 transcriptome data sets also contained a significant number of genes known to regulate synapse formation or function.Increased nuclear DSCAM levels inhibit synapse formation
Publications: 1 Organism: Homo Sapiens
+ BDNFup-regulates img/indirect-activation.png Synaptic_plasticity 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-265063 Homo sapiens
pmid sentence
BDNF is a central driver of synaptic plasticity and memory formation and its decreased levels may contribute to the degeneration of specific neuronal populations and progressive atrophy of neurons in the AD-affected brain
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
Pathways:Dopaminergic Synapse, GABAergic synapse , Rett syndrome
+ FKBP5up-regulates img/indirect-activation.png Synaptic_plasticity 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-265798 Mus musculus Brain
pmid sentence
Loss of FKBP5 Affects Neuron Synaptic Plasticity | In this study, a reduction in LTP in Fkbp5 knockout (KO) mice was observed when compared to WT mice, which correlated with changes to the glutamatergic and GABAergic signaling pathways.
Publications: 1 Organism: Mus Musculus
Pathways:Rett syndrome
+ DLG4up-regulates img/indirect-activation.png Synaptic_plasticity 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-264053 Homo sapiens Neuron
pmid sentence
Postsynaptic density 95 (PSD-95) is an important regulator of synaptic structure and plasticity.
Publications: 1 Organism: Homo Sapiens
Pathways:Glutamatergic synapse
+ AMPAup-regulates img/indirect-activation.png Synaptic_plasticity 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-267783 in vitro
pmid sentence
AMPAR surface diffusion tunes short-term plasticity. | Accordingly, recent studies have suggested that about half of synaptic AMPARs are organized in nanoclusters that are aligned with presynaptic transmitter release sites, supporting the concept of functional nanocolumns to increase the fidelity of fast excitatory transmission. This peculiar organization might also support the proposal that we made 10 years ago that fast surface diffusion of AMPARs tunes frequency-dependent short-term plasticity (FD-STP) by allowing the fast replacement of desensitized receptors by naïve ones.
Identifier Residue Sequence Organism Cell Line
SIGNOR-270304 in vitro
pmid sentence
AMPAR surface diffusion tunes short-term plasticity. | Accordingly, recent studies have suggested that about half of synaptic AMPARs are organized in nanoclusters that are aligned with presynaptic transmitter release sites, supporting the concept of functional nanocolumns to increase the fidelity of fast excitatory transmission. This peculiar organization might also support the proposal that we made 10 years ago that fast surface diffusion of AMPARs tunes frequency-dependent short-term plasticity (FD-STP) by allowing the fast replacement of desensitized receptors by naïve ones.
Publications: 2 Organism: In Vitro
Pathways:Dopaminergic Synapse, Glutamatergic synapse
+ LRFN5up-regulates img/indirect-activation.png Synaptic_plasticity 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-264093 Homo sapiens Neuron
pmid sentence
The SALM (synaptic adhesion-like molecule) family of adhesion molecules, also known as Lrfn, belongs to the superfamily of leucine-rich repeat (LRR)-containing adhesion molecules. Proteins of the SALM family, which includes five known members (SALMs 1-5), have been implicated in the regulation of neurite outgrowth and branching, and synapse formation and maturation.SALM3 and SALM5, but not other SALMs, possess synaptogenic activity, inducing presynaptic differentiation in contacting axons.
Identifier Residue Sequence Organism Cell Line
SIGNOR-264085 Homo sapiens Neuron
pmid sentence
These results suggest that postsynaptic SALM5 promotes synapse development by trans-synaptically interacting with presynaptic LAR-RPTPs and is important for the regulation of excitatory synaptic strength.
Publications: 2 Organism: Homo Sapiens
+ KIRREL3up-regulates img/indirect-activation.png Synaptic_plasticity 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-269077 Homo sapiens
pmid sentence
We demonstrate that ectopic Kirrel3 expression in CA1 neurons specifically induces ectopic DG synapse formation, providing direct evidence that Kirrel3 plays an instructive role in synapse development.
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ DSCAMdown-regulates img/indirect_inhibition.png Synaptic_plasticity 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-264321 Homo sapiens Neuron
pmid sentence
The DSCAM/L1 transcriptome data sets also contained a significant number of genes known to regulate synapse formation or function.Increased nuclear DSCAM levels inhibit synapse formation
Publications: 1 Organism: Homo Sapiens
+ PKAup-regulates img/indirect-activation.png Synaptic_plasticity 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-264961 Homo sapiens Neuron
pmid sentence
PKA is activated by Group I mGluRs in ACC neurons. The cAMP signaling pathway contributes to the activity-dependent synaptic plasticity in the anterior cingulate cortex
Publications: 1 Organism: Homo Sapiens
Tissue: Anterior Cingulate Cortex
Pathways:Dopaminergic Synapse, Glutamatergic synapse, GABAergic synapse , Oxytocin signaling
+ GPHNup-regulates img/indirect-activation.png Synaptic_plasticity 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-264975 Homo sapiens Neuron
pmid sentence
Gephyrin is believed to act as a scaffold at inhibitory synapses, in a manner analogous to that of the prototypic excitatory synaptic scaffold, PSD-95. The best-known function of gephyrin is to bring the inhibitory synaptic receptors and to stabilize them at the inhibitory synapses. gephyrin interacts with NL-2 and collybistin, suggesting that it may be critical for the maturation or maintenance of inhibitory synapses.
Publications: 1 Organism: Homo Sapiens
Pathways:GABAergic synapse
+ PTPRFup-regulates img/indirect-activation.png Synaptic_plasticity 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-264090 Homo sapiens Neuron
pmid sentence
LAR (for leukocyte common antigen-related) is a family of receptor protein tyrosine phosphatases (LAR-RPTPs) with three known members: LAR/PTPRF, PTPδ/PTPRD, and PTPσ/PTPRS. In mammals, LAR-RPTPs have been shown to regulate dendrite and excitatory synapse development and maintenance
Publications: 1 Organism: Homo Sapiens
+ NLGN2up-regulates img/indirect-activation.png Synaptic_plasticity 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-264977 Homo sapiens Neuron
pmid sentence
Gephyrin is believed to act as a scaffold at inhibitory synapses, in a manner analogous to that of the prototypic excitatory synaptic scaffold, PSD-95. The best-known function of gephyrin is to bring the inhibitory synaptic receptors and to stabilize them at the inhibitory synapses. gephyrin interacts with NL-2 and collybistin, suggesting that it may be critical for the maturation or maintenance of inhibitory synapses.
Publications: 1 Organism: Homo Sapiens
Pathways:GABAergic synapse
+ GRIA2up-regulates img/indirect-activation.png Synaptic_plasticity 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-265796 in vitro
pmid sentence
AMPAR surface diffusion tunes short-term plasticity. | Accordingly, recent studies have suggested that about half of synaptic AMPARs are organized in nanoclusters that are aligned with presynaptic transmitter release sites, supporting the concept of functional nanocolumns to increase the fidelity of fast excitatory transmission. This peculiar organization might also support the proposal that we made 10 years ago that fast surface diffusion of AMPARs tunes frequency-dependent short-term plasticity (FD-STP) by allowing the fast replacement of desensitized receptors by naïve ones.
Publications: 1 Organism: In Vitro
Pathways:Rett syndrome
+ CREB1up-regulates img/indirect-activation.png Synaptic_plasticity 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-265773 Mus musculus
pmid sentence
These findings, together with studies in Aplysia and Drosophila, strongly suggest that CREB is an evolutionary conserved component of the molecular cascade of events leading to memory consolidation.
Publications: 1 Organism: Mus Musculus
Tissue: Brain
Pathways:Dopaminergic Synapse, GABAergic synapse , Oxytocin signaling, Rett syndrome
+ PTPRDup-regulates img/indirect-activation.png Synaptic_plasticity 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-264089 Homo sapiens Neuron
pmid sentence
LAR (for leukocyte common antigen-related) is a family of receptor protein tyrosine phosphatases (LAR-RPTPs) with three known members: LAR/PTPRF, PTPδ/PTPRD, and PTPσ/PTPRS. In mammals, LAR-RPTPs have been shown to regulate dendrite and excitatory synapse development and maintenance
Publications: 1 Organism: Homo Sapiens
+ PTPRSup-regulates img/indirect-activation.png Synaptic_plasticity 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-264091 Homo sapiens Neuron
pmid sentence
LAR (for leukocyte common antigen-related) is a family of receptor protein tyrosine phosphatases (LAR-RPTPs) with three known members: LAR/PTPRF, PTPδ/PTPRD, and PTPσ/PTPRS. In mammals, LAR-RPTPs have been shown to regulate dendrite and excitatory synapse development and maintenance
Publications: 1 Organism: Homo Sapiens
+ RELNup-regulates img/indirect-activation.png Synaptic_plasticity 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-265772 Mus musculus
pmid sentence
Reln, encoding an extracellular signaling molecule essential for neuronal lamination and synaptic plasticity
Publications: 1 Organism: Mus Musculus
Pathways:Rett syndrome
+ UPF2up-regulates img/indirect-activation.png Synaptic_plasticity 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-265235 Homo sapiens
pmid sentence
Our data indicate that proper synaptic plasticity and cognitive function requires UPF2. 
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ calcium(2+)up-regulates img/indirect-activation.png Synaptic_plasticity 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-264955 Homo sapiens Neuron
pmid sentence
Ca2+ is arguably the most important second messenger in the brain because of its pivotal roles in presynaptic neurotransmitter release, postsynaptic responses, and plasticity induction.
Publications: 1 Organism: Homo Sapiens
Pathways:Dopaminergic Synapse, Glutamatergic synapse, GABAergic synapse , Oxytocin signaling
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