Summary

Name XPO5
Full Name Exportin-5
Synonyms Exp5, Ran-binding protein 21 | KIAA1291, RANBP21
Primary ID Q9HAV4
Links - -
Type protein
Relations 11
Function Mediates the nuclear export of proteins bearing a double-stranded RNA binding domain (dsRBD) and double-stranded RNAs (cargos). XPO5 in the nucleus binds cooperatively to the RNA and to the GTPase Ran in its active GTP-bound form. Proteins containing dsRBDs can associate with this trimeric complex through the RNA. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause disassembly of the complex and release of the cargo from the export receptor. XPO5 then returns to the nuclear compartment by diffusion through the nuclear pore complex, to mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Overexpression may in some circumstances enhance RNA-mediated gene silencing (RNAi). Mediates nuclear export of isoform 5 of ADAR/ADAR1 in a RanGTP-dependent manner.; FUNCTION

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ MAPK1down-regulates activity img/direct_inhibition.png phosphorylation XPO5 0.301
Publications: 3 Organism: Homo Sapiens
+ MAPK3down-regulates activity img/direct_inhibition.png phosphorylation XPO5 0.312
Publications: 3 Organism: Homo Sapiens
+ ERK1/2down-regulates activity img/direct_inhibition.png phosphorylation XPO5 0.2
Publications: 3 Organism: Homo Sapiens
+ Gbetadown-regulates activity img/direct_inhibition.png phosphorylation XPO5 0.2
Publications: 1 Organism: Homo Sapiens
+ PIN1down-regulates activity img/direct_inhibition.png isomerization XPO5 0.2
Publications: 1 Organism: Homo Sapiens