3.0
Summary
| Name |  CLK4View Modifications |
| Full Name | Dual specificity protein kinase CLK4 |
| Synonyms | CDC-like kinase 4 |
| Primary ID | Q9HAZ1 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Function | Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates SRSF1 and SRSF3. Required for the regulation of alternative splicing of MAPT/TAU. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CLK4 | up-regulates activity 
phosphorylation
|
NR5A1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CLK4 | down-regulates 
phosphorylation
|
ABL1 | 0.276 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CLK4 | down-regulates quantity by destabilization
phosphorylation
|
MITF | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CLK4 | up-regulates activity
phosphorylation
|
SRSF1 | 0.365 |
| Publications: | 1 | Organism: | In Vitro | |