3.0
Summary
| Name |  PIDD1View Modifications |
| Full Name | p53-induced death domain-containing protein 1 |
| Synonyms | Leucine-rich repeat and death domain-containing protein | LRDD, PIDD |
| Primary ID | Q9HB75 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | Component of the DNA damage/stress response pathway that functions downstream of p53/TP53 and can either promote cell survival or apoptosis (PubMed:10973264, PubMed:15073321, PubMed:16360037, PubMed:17159900). Associated with CRADD and the CASP2 caspase, it forms the PIDDosome a complex that activates CASP2 and triggers apoptosis (PubMed:15073321, PubMed:17159900). Associated with IKBKG and RIPK1, it enhances sumoylation and ubiquitination of IKBKG which is important for activation of the transcription factor NF-kappa-B (PubMed:16360037, PubMed:17159900). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | ATM | up-regulates activity 
phosphorylation
|
PIDD1 | 0.622 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ANKRD26 | up-regulates activity
relocalization
|
PIDD1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PIDD1 | form complex 
binding
|
Caspase-2 PIDDosome | 0.845 |
| Publications: | 1 | Organism: | Homo Sapiens | |