3.0
Summary
| Name |  MSL2View Modifications |
| Full Name | E3 ubiquitin-protein ligase MSL2 |
| Synonyms | E3 ubiquitin-protein transferase MSL2, Male-specific lethal 2-like 1, MSL2-like 1, Male-specific lethal-2 homolog, MSL-2, Male-specific lethal-2 homolog 1, RING finger protein 184 | KIAA1585, MSL2L1, RNF184 |
| Primary ID | Q9HCI7 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure. Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | MSL2 | down-regulates activity 
monoubiquitination
|
H2BC21 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MSL2 | form complex 
binding
|
MSL acetyltransferase | 0.893 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | HeLa Cell | |||
| + | MSL2 | down-regulates activity
ubiquitination
|
TP53 | 0.378 |
| Publications: | 1 | Organism: | Homo Sapiens | |