| + |
CSNK1G1 | up-regulates quantity by stabilization 
phosphorylation
|
LYN |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275396 |
Ser13 |
SKGKDSLsDDGVDLK |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 33004926 |
Although there have been more than 40 reports of mass spectrometric studies on phosphorylation at Lyn-S13, the kinase responsible remained unclear. We succeeded in identifying casein kinase 1γ (CK1γ) as the kinase responsible for phosphorylation of Lyn-S13. In HEK293 cells co-expressing Lyn and CK1γ, the phosphorylation level of Lyn-S13 increased significantly. we concluded that S-palmitoylated CK1γ encounters N-myristoylated Lyn and specifically phosphorylates the Ser-13 residue at the Golgi during intracellular protein traffic, as shown schematically in Fig. 8. Phosphorylated dual-lipid-modified Lyn and S-palmitoylated CK1γ are then transported from the Golgi to the plasma membrane. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CSNK1G1 | down-regulates activity 
phosphorylation
|
FOXO1 |
0.471 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250822 |
Ser322 |
PRTSSNAsTISGRLS |
in vitro |
|
| pmid |
sentence |
| 11980723 |
Phosphorylation of Ser319 forms a consensus sequence for phosphorylation by CK1, allowing it to phosphorylate Ser322, which in turn primes the CK1-catalysed phosphorylation of Ser325 | Multisite phosphorylation of the region containing Ser319, Ser322, Ser325 and Ser329 provides a signal for the nuclear exclusion of FKHR |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250821 |
Ser325 |
SSNASTIsGRLSPIM |
in vitro |
|
| pmid |
sentence |
| 11980723 |
Phosphorylation of Ser319 forms a consensus sequence for phosphorylation by CK1, allowing it to phosphorylate Ser322, which in turn primes the CK1-catalysed phosphorylation of Ser325 | Multisite phosphorylation of the region containing Ser319, Ser322, Ser325 and Ser329 provides a signal for the nuclear exclusion of FKHR |
|
| Publications: |
2 |
Organism: |
In Vitro |
| + |
CSNK1G1 | down-regulates activity
phosphorylation
|
FOXO |
0.471 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252901 |
Ser322 |
PRTSSNAsTISGRLS |
in vitro |
|
| pmid |
sentence |
| 11980723 |
Phosphorylation of Ser319 forms a consensus sequence for phosphorylation by CK1, allowing it to phosphorylate Ser322, which in turn primes the CK1-catalysed phosphorylation of Ser325 | Multisite phosphorylation of the region containing Ser319, Ser322, Ser325 and Ser329 provides a signal for the nuclear exclusion of FKHR |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252902 |
Ser325 |
SSNASTIsGRLSPIM |
in vitro |
|
| pmid |
sentence |
| 11980723 |
Phosphorylation of Ser319 forms a consensus sequence for phosphorylation by CK1, allowing it to phosphorylate Ser322, which in turn primes the CK1-catalysed phosphorylation of Ser325 | Multisite phosphorylation of the region containing Ser319, Ser322, Ser325 and Ser329 provides a signal for the nuclear exclusion of FKHR |
|
| Publications: |
2 |
Organism: |
In Vitro |
| + |
CSNK1G1 | up-regulates
phosphorylation
|
LRP6 |
0.527 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-143029 |
Thr1479 |
SSSSTKGtYFPAILN |
Homo sapiens |
|
| pmid |
sentence |
| 16341016 |
Ck1gamma is associated with lrp6, which has multiple, modular ck1 phosphorylation sites. Wnt treatment induces the rapid ck1gamma-mediated phosphorylation of these sites within lrp6 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AMER1 | up-regulates
binding
|
CSNK1G1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-171889 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21304492 |
Amer1 binds ck1gamma, recruits axin and gsk3beta to the plasma membrane and promotes complex formation between axin and lrp6. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
CSNK1G1
- 
- 