| + |
AMER1 | down-regulates activity 
binding
|
CTNNB1 |
0.767 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217950 |
|
|
Homo sapiens |
HEK-293 Cell, SW-480 Cell |
| pmid |
sentence |
| 21498506 |
We show that Amer1 binds directly to beta-catenin via a novel interaction motif, the REA repeats. This amino acid motif, including the core sequence arginine, glutamic acid and alanine, and this REA repeats mediate binding of Amer1 to the armadillo repeats of beta-catenin. The data suggest that Amer1 exerts its negative regulatory role in Wnt signaling by acting as a scaffold protein for the beta-catenin destruction complex and promoting stabilization of Axin at the plasma membrane. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AMER1 | up-regulates activity 
binding
|
LRP6 |
0.455 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-24265 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 21304492 |
Knockdown of Amer1 reduces Wnt-induced LRP6 phosphorylation, Axin translocation to the plasma membrane and formation of LRP6 signalosomesThe generation of PtdIns(4,5)P2 in regions of receptor activity triggers the recruitment of Amer1 proteins, which in turn promote LRP6 phosphorylation by recruiting Axin/GSK3_ and CK1gamma to LRP6. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AMER1 | up-regulates activity
relocalization
|
GSK3B |
0.393 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-171892 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 21304492 |
Amer1 binds ck1gamma, recruits axin and gsk3beta to the plasma membrane and promotes complex formation between axin and lrp6. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AMER1 | up-regulates activity
relocalization
|
GSK3B/Axin/APC |
0.633 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-227991 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21304492 |
Amer1 binds ck1gamma, recruits axin and gsk3beta to the plasma membrane and promotes complex formation between axin and lrp6. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AMER1 | up-regulates
relocalization
|
APC |
0.726 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199375 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23151663 |
Apc membrane recruitment protein 1 (amer1;alsoknownas wtx) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AMER1 | up-regulates
binding
|
CSNK1G1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-171889 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21304492 |
Amer1 binds ck1gamma, recruits axin and gsk3beta to the plasma membrane and promotes complex formation between axin and lrp6. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AMER1 | up-regulates activity
relocalization
|
AXIN1 |
0.78 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-171886 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21304492 |
Amer1 binds ck1gamma, recruits axin and gsk3beta to the plasma membrane and promotes complex formation between axin and lrp6. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AMER1 | up-regulates
binding
|
WT1 |
0.45 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-185644 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19416806 |
Wtx binds wt1, a zinc-finger transcription factor that is inactivated in wilms tumor. / the ability of wtx to enhance wt1-mediated transactivation suggests a physiologically significant interaction between these 2 tumor suppressors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
AMER1
- 
- 