Relation Results

Summary

Name MID1IP1
Full Name Mid1-interacting protein 1
Synonyms Gastrulation-specific G12-like protein, Mid1-interacting G12-like protein, Protein STRAIT11499, Spot 14-related protein, S14R, Spot 14-R | MIG12
Primary ID Q9NPA3
Links - -
Type protein
Relations 3
Function Plays a role in the regulation of lipogenesis in liver. Up-regulates ACACA enzyme activity. Required for efficient lipid biosynthesis, including triac ...
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Type: Score: Layout: SPV 
0.3780.5050.281MID1IP1ACACATHRSPACACB

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Relations
Regulator
Mechanism
target
score ℹ
+ MID1IP1up-regulates activity img/direct-activation.png binding ACACA 0.378
Identifier Residue Sequence Organism Cell Line
SIGNOR-267111 Cricetulus griseus CHO-K1 Cell
pmid sentence
Recently, we reported the discovery that MIG12, a 183 amino acid protein, binds to ACC1 and ACC2, which induces polymerization and subsequently increases the enzymatic activity of the protein
Publications: 1 Organism: Cricetulus Griseus
+ THRSPdown-regulates activity img/direct_inhibition.png binding MID1IP1 0.505
Identifier Residue Sequence Organism Cell Line
SIGNOR-267113 Cricetulus griseus CHO-K1 Cell
pmid sentence
In the current study, we have determined the crystal structure of mouse S14 to 2.65-Å resolution. The structure of S14 reveals a helical protein arranged as a symmetric dimer. Cultured cell experiments indicate that S14 can form heterodimers with MIG12, suggesting a mechanism through which S14 could modulate ACC activity and subsequently rates of fatty acid synthesis via heterodimer formation with MIG12.In the current study, we have shown that regulating the levels of S14∶MIG12 heterodimers regulates the ability of MIG12 to activate ACC. Increasing S14∶MIG12 heterodimers by the overexpression of S14 resulted in decreased ACC activity and polymerization, whereas decreasing S14∶MIG12 heterodimers by knockdown of S14 increased ACC activity and polymerization.
Publications: 1 Organism: Cricetulus Griseus
+ MID1IP1up-regulates activity img/direct-activation.png binding ACACB 0.281
Identifier Residue Sequence Organism Cell Line
SIGNOR-267112 Cricetulus griseus
pmid sentence
Recently, we reported the discovery that MIG12, a 183 amino acid protein, binds to ACC1 and ACC2, which induces polymerization and subsequently increases the enzymatic activity of the protein
Publications: 1 Organism: Cricetulus Griseus
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