Summary

Name ACACA
Full Name Acetyl-CoA carboxylase 1
Synonyms ACC1, ACC-alpha | ACAC, ACC1, ACCA
Primary ID Q13085
Links - -
Type protein
Relations 18
Pathways Fatty Acid Synthesis, Leptin Signaling
Function Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis (PubMed:20952656, PubMed:20457939, PubMed:29899443). This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed:20952656, PubMed:20457939, PubMed:29899443).

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▶Modifications Tables

Relations


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Regulator Mechanism target score ℹ
+ PRKACAdown-regulates activity img/direct_inhibition.png phosphorylation ACACA 0.2
Publications: 1 Organism: In Vitro
+ PRKAA1down-regulates activity img/direct_inhibition.png phosphorylation ACACA 0.713
Publications: 1 Organism: Rattus Norvegicus
+ CSNK2A1