Summary

Name ACACB
Full Name Acetyl-CoA carboxylase 2
Synonyms ACC-beta | ACC2, ACCB, ACC2, ACCB
Primary ID O00763
Links - -
Type protein
Relations 7
Pathways Fatty Acid Synthesis
Function Mitochondrial enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA and plays a central role in fatty acid metabolism (PubMed:16854592, PubMed:19236960, PubMed:20457939, PubMed:20952656, PubMed:19900410, PubMed:26976583). Catalyzes a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed:19236960, PubMed:20457939, PubMed:20952656, PubMed:26976583). Through the production of malonyl-CoA that allosterically inhibits carnitine palmitoyltransferase 1 at the mitochondria, negatively regulates fatty acid oxidation (By similarity). Together with its cytosolic isozyme ACACA, which is involved in de novo fatty acid biosynthesis, promotes lipid storage (By similarity).

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates activity img/direct_inhibition.png phosphorylation ACACB 0.636
Publications: 2 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png binding ACACB 0.261
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination ACACB 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png chemical modification malonyl-CoA 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Fatty Acid Synthesis
+ up-regulates activity img/direct-activation.png binding ACACB 0.283
Publications: 1 Organism: Cricetulus Griseus
+ down-regulates quantity img/direct_inhibition.png chemical modification acetyl-CoA 0.8
Publications: 1 Organism: Homo Sapiens
Pathways:Fatty Acid Synthesis