Summary

Name RTN4
Full Name Reticulon-4
Synonyms Foocen, Neurite outgrowth inhibitor, Nogo protein, Neuroendocrine-specific protein, NSP, Neuroendocrine-specific protein C homolog, RTN-x, Reticulon-5 | KIAA0886, NOGO
Primary ID Q9NQC3
Links - -
Type protein
Relations 2
Function Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:27619977, PubMed:25612671, PubMed:24262037). They regulate membrane morphogenesis in the ER by promoting tubular ER production (PubMed:27619977, PubMed:25612671, PubMed:24262037, PubMed:27786289). They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412). However each isoform have specific functions mainly depending on their tissue expression specificities (Probable).

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Modifications Tables

Relations

Regulator Mechanism target score
+ img/unknown.png phosphorylation RTN4 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding LINGO1 0.654
Publications: 1 Organism: Homo Sapiens