+ |
PRKG1 | up-regulates activity
phosphorylation
|
RGS18 |
0.34 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-273785 |
Ser216 |
PTNLRRRsRSFTCNE |
Homo sapiens |
Blood Platelet |
pmid |
sentence |
24244663 |
Cyclic AMP- and cyclic GMP-dependent kinases (PKA, PKG) inhibit the interaction of RGS18 and 14-3-3 by phosphorylating S216. S216 phosphorylation might activate PP1 leading to dephosphorylation of both 14-3-3 binding sites, S49 and S218, and detachment of 14-3-3. Removal of 14-3-3 activates RGS18 to turn off Gq signaling thus contributing to platelet inhibition. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
PRKACA | up-regulates activity
phosphorylation
|
RGS18 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-273786 |
Ser216 |
PTNLRRRsRSFTCNE |
Homo sapiens |
Blood Platelet |
pmid |
sentence |
24244663 |
Cyclic AMP- and cyclic GMP-dependent kinases (PKA, PKG) inhibit the interaction of RGS18 and 14-3-3 by phosphorylating S216. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
14-3-3 | down-regulates activity
binding
|
RGS18 |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-273787 |
|
|
Homo sapiens |
Blood Platelet |
pmid |
sentence |
24244663 |
Cyclic AMP- and cyclic GMP-dependent kinases (PKA, PKG) inhibit the interaction of RGS18 and 14-3-3 by phosphorylating S216. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |