3.0
Summary
| Name |  RAD18View Modifications |
| Full Name | E3 ubiquitin-protein ligase RAD18 |
| Synonyms | Postreplication repair protein RAD18, hHR18, hRAD18, RING finger protein 73 | RNF73 |
| Primary ID | Q9NS91 |
| Links |  -  -  |
| Type | protein |
| Relations | 7 |
| Function | E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. Has ssDNA binding activity. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | RAD18 | up-regulates activity 
ubiquitination
|
TP53BP1 | |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RAD18 | up-regulates activity
ubiquitination
|
PCNA | |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CDC7 |
phosphorylation
|
RAD18 | 0.5 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | Ub:E2 | up-regulates activity
ubiquitination
|
RAD18 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RNF8 | up-regulates
binding
|
RAD18 | 0.425 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RAD18 | up-regulates activity
ubiquitination
|
FANCD2 | |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RAD18 | up-regulates
ubiquitination
|
PCNA | 0.841 |
| Publications: | 1 | Organism: | Homo Sapiens | |