Summary

Name ATG3
Full Name Ubiquitin-like-conjugating enzyme ATG3
Synonyms Autophagy-related protein 3, APG3-like, hApg3, Protein PC3-96 | APG3, APG3L
Primary ID Q9NT62
Links - -
Type protein
Relations 5
Pathways Autophagy
Function E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). The ATG12-ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8-like proteins from ATG3 to phosphatidylethanolamine (PE). This step is required for the membrane association of ATG8-like proteins. The formation of the ATG8-phosphatidylethanolamine conjugates is essential for autophagy and for the cytoplasm to vacuole transport (Cvt). Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with ATG3. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.

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Relations

Regulator Mechanism target score ℹ
+ MAP1LC3Aup-regulates img/direct-activation.png binding ATG3 0.85
Publications: 1 Organism: Homo Sapiens
+ ATG3up-regulates activity img/direct-activation.png binding GABARAP 0.842
Publications: 1 Organism: In Vitro
Pathways:Autophagy
+ ATG3up-regulates activity img/direct-activation.png binding GABARAPL2 0.869
Publications: 1 Organism: In Vitro
Pathways:Autophagy
+ MAP1LC3Bup-regulates img/direct-activation.png binding ATG3 0.828
Publications: 1 Organism: Homo Sapiens
+ MAP1LC3Cup-regulates activity img/direct-activation.png binding ATG3 0.773
Publications: 1 Organism: Mus Musculus
Pathways:Autophagy