Summary

Name SACM1L
Full Name Phosphatidylinositol-3-phosphatase SAC1
Synonyms Suppressor of actin mutations 1-like protein | KIAA0851
Primary ID Q9NTJ5
Links - -
Type protein
Relations 2
Pathways COVID-19 Causal Network, SARS-CoV ATTACHMENT AND ENTRY
Function Phosphoinositide phosphatase which catalyzes the hydrolysis of phosphatidylinositol 4-phosphate (PtdIns(4)P) (PubMed:24209621, PubMed:27044890, PubMed:29461204, PubMed:30659099). Can also catalyze the hydrolysis of phosphatidylinositol 3-phosphate (PtdIns(3)P) and has low activity towards phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2) (By similarity). Shows a very robust PtdIns(4)P phosphatase activity when it binds PtdIns(4)P in a 'cis' configuration in the cellular environment, with much less activity seen when it binds PtdIns(4)P in 'trans' configuration (PubMed:29461204, PubMed:24209621, PubMed:30659099). PtdIns(4)P phosphatase activity (when it binds PtdIns(4)P in 'trans' configuration) is enhanced in the presence of PLEKHA3 (PubMed:30659099).

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Relations

Regulator Mechanism target score ℹ
+ SACM1Ldown-regulates quantity img/direct_inhibition.png chemical modification phosphatidylinositol 4-phosphate 0.8
Publications: 1 Organism: Chlorocebus Aethiops
Pathways:COVID-19 Causal Network, SARS-CoV ATTACHMENT AND ENTRY
+ SACM1Ldown-regulates img/indirect_inhibition.png Receptor_mediated_ endocytosis 0.7
Publications: 1 Organism: Chlorocebus Aethiops
Pathways:COVID-19 Causal Network, SARS-CoV ATTACHMENT AND ENTRY