Relation Results

Summary

Name NDE1
Full Name Nuclear distribution protein nudE homolog 1
Synonyms NudE | NUDE
Primary ID Q9NXR1
Links - -
Type protein
Relations 12
Function Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the development of the cerebral cortex. May regul ...
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Type: Score: Layout: SPV 
0.3760.5420.3960.652MAPK1NDE1CyclinB/CDK1PRKACACDK1

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ MAPK1up-regulates activity img/direct-activation.png phosphorylation NDE1 0.376
Identifier Residue Sequence Organism Cell Line
SIGNOR-249421 Ser239 FRRGLDDsTGGTPLT Homo sapiens HEK-293 Cell
pmid sentence
Moreover, both proteins were phosphorylated by Cdc2 and Erk2 in vitro. In the case of Nudel, the phosphorylation sites were also located in the S/TP motifs. Detailed mutagenesis study indicated that T219, S242, and T245 were phosphorylated by Cdc2, while T219 and T245 were phosphorylated by Erk2.|Phosphorylation of Nudel in M phase appears to positively modulate dynein motor activity. Both phosphorylated and unphosphorylated forms of Nudel were transported by dynein (Fig. 7 and 9 and data not shown), indicating that neither of them inactivated the dynein motor. On the other hand, both phospho-Nudel and Nudelpmt5 bound Lis1 more strongly than Nudel or Nudelmt5 did
Identifier Residue Sequence Organism Cell Line
SIGNOR-249422 Thr215 ATGSVPStPIAHRGP Homo sapiens HEK-293 Cell
pmid sentence
Moreover, both proteins were phosphorylated by Cdc2 and Erk2 in vitro. In the case of Nudel, the phosphorylation sites were also located in the S/TP motifs. Detailed mutagenesis study indicated that T219, S242, and T245 were phosphorylated by Cdc2, while T219 and T245 were phosphorylated by Erk2.|Phosphorylation of Nudel in M phase appears to positively modulate dynein motor activity. Both phosphorylated and unphosphorylated forms of Nudel were transported by dynein (Fig. 7 and 9 and data not shown), indicating that neither of them inactivated the dynein motor. On the other hand, both phospho-Nudel and Nudelpmt5 bound Lis1 more strongly than Nudel or Nudelmt5 did
Identifier Residue Sequence Organism Cell Line
SIGNOR-274078 in vitro
pmid sentence
We found that Nudel and NudE were also phosphorylated in M phase (Fig. ​(Fig.22 and ​and3).3). First, Nudel and NudE were specifically phosphorylated in M phase. Moreover, both proteins were phosphorylated by Cdc2 and Erk2 in vitro.Due to conservation of the S/TP motifs, NudE may also be phosphorylated at similar sites by these kinases, though it contains an additional potential Cdk site at S282 (SPNR).
Publications: 3 Organism: Homo Sapiens, In Vitro
+ CyclinB/CDK1up-regulates quantity by stabilization img/direct-activation.png phosphorylation NDE1 0.542
Identifier Residue Sequence Organism Cell Line
SIGNOR-274083 Ser282 RNLVYDQsPNRTGGP Homo sapiens HEK-293 Cell
pmid sentence
Here, we demonstrate that Su48 can associate with Nde1. Moreover, we found that Nde1 is subjected to phosphorylation in vivo. In particular, we identified six putative Cdc2 phosphorylation sites in Nde1 and found that alteration of these sites diminishes phosphorylation by Cdc2 in vitro and affects the stability of Su48-Nde1 interactions and the centrosomal localization of Nde1.
Identifier Residue Sequence Organism Cell Line
SIGNOR-274087 Thr191 QKQEKPRtPMPSSVE Homo sapiens HEK-293 Cell
pmid sentence
Here, we demonstrate that Su48 can associate with Nde1. Moreover, we found that Nde1 is subjected to phosphorylation in vivo. In particular, we identified six putative Cdc2 phosphorylation sites in Nde1 and found that alteration of these sites diminishes phosphorylation by Cdc2 in vitro and affects the stability of Su48-Nde1 interactions and the centrosomal localization of Nde1.
Identifier Residue Sequence Organism Cell Line
SIGNOR-274082 Thr215 ATGSVPStPIAHRGP Homo sapiens HEK-293 Cell
pmid sentence
Here, we demonstrate that Su48 can associate with Nde1. Moreover, we found that Nde1 is subjected to phosphorylation in vivo. In particular, we identified six putative Cdc2 phosphorylation sites in Nde1 and found that alteration of these sites diminishes phosphorylation by Cdc2 in vitro and affects the stability of Su48-Nde1 interactions and the centrosomal localization of Nde1.
Identifier Residue Sequence Organism Cell Line
SIGNOR-274085 Thr228 GPSSSLNtPGSFRRG Homo sapiens HEK-293 Cell
pmid sentence
Here, we demonstrate that Su48 can associate with Nde1. Moreover, we found that Nde1 is subjected to phosphorylation in vivo. In particular, we identified six putative Cdc2 phosphorylation sites in Nde1 and found that alteration of these sites diminishes phosphorylation by Cdc2 in vitro and affects the stability of Su48-Nde1 interactions and the centrosomal localization of Nde1.
Identifier Residue Sequence Organism Cell Line
SIGNOR-274084 Thr243 LDDSTGGtPLTPAAR Homo sapiens HEK-293 Cell
pmid sentence
Here, we demonstrate that Su48 can associate with Nde1. Moreover, we found that Nde1 is subjected to phosphorylation in vivo. In particular, we identified six putative Cdc2 phosphorylation sites in Nde1 and found that alteration of these sites diminishes phosphorylation by Cdc2 in vitro and affects the stability of Su48-Nde1 interactions and the centrosomal localization of Nde1.
Identifier Residue Sequence Organism Cell Line
SIGNOR-274086 Thr246 STGGTPLtPAARISA Homo sapiens HEK-293 Cell
pmid sentence
Here, we demonstrate that Su48 can associate with Nde1. Moreover, we found that Nde1 is subjected to phosphorylation in vivo. In particular, we identified six putative Cdc2 phosphorylation sites in Nde1 and found that alteration of these sites diminishes phosphorylation by Cdc2 in vitro and affects the stability of Su48-Nde1 interactions and the centrosomal localization of Nde1.
Publications: 6 Organism: Homo Sapiens
+ PRKACAup-regulates img/direct-activation.png phosphorylation NDE1 0.396
Identifier Residue Sequence Organism Cell Line
SIGNOR-174410 Thr131 LERAKRAtIMSLEDF Homo sapiens
pmid sentence
Here, we demonstrate that disc1 and pde4 modulate nde1 phosphorylation by camp-dependent protein kinase a (pka) and identify a novel pka substrate site on nde1 at threonine-131 (t131).Since phosphorylated t131 is detectable at multiple subcellular locations (centrosome, nucleus, postsynaptic density, proximal axon), there is potential for disc1/pde4 to influence several important brain processes that critically depend on the nde1/ndel1/lis1 comple
Publications: 1 Organism: Homo Sapiens
Tissue: Brain
+ CDK1up-regulates img/direct-activation.png phosphorylation NDE1 0.652
Identifier Residue Sequence Organism Cell Line
SIGNOR-146734 Homo sapiens
pmid sentence
We found that nde1 is subjected to phosphorylation in vivo. In particular, we identified six putative cdc2 phosphorylation sites in nde1 and found that alteration of these sites diminishes phosphorylation by cdc2 in vitro and affects the stability of su48-nde1 interactions and the centrosomal localization of nde1.
Publications: 1 Organism: Homo Sapiens
+ CDK1up-regulates activity img/direct-activation.png phosphorylation NDE1 0.652
Identifier Residue Sequence Organism Cell Line
SIGNOR-274077 in vitro
pmid sentence
We found that Nudel and NudE were also phosphorylated in M phase (Fig. ​(Fig.22 and ​and3).3). First, Nudel and NudE were specifically phosphorylated in M phase. Moreover, both proteins were phosphorylated by Cdc2 and Erk2 in vitro.Due to conservation of the S/TP motifs, NudE may also be phosphorylated at similar sites by these kinases, though it contains an additional potential Cdk site at S282 (SPNR).
Publications: 1 Organism: In Vitro
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