Summary

Name ARHGEF12
Full Name Rho guanine nucleotide exchange factor 12
Synonyms Leukemia-associated RhoGEF | KIAA0382, LARG
Primary ID Q9NZN5
Links - -
Type protein
Relations 5
Function May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13.

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Relations

Regulator Mechanism target score ℹ
+ GNA12up-regulates activity img/direct-activation.png binding ARHGEF12 0.757
Publications: 1 Organism: Mus Musculus
+ GNAQup-regulates activity img/direct-activation.png binding ARHGEF12 0.431
Publications: 1 Organism: Mus Musculus
+ GNA13up-regulates activity img/direct-activation.png binding ARHGEF12 0.764
Publications: 1 Organism: Mus Musculus
+ ARHGEF12up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RHOA 0.902
Publications: 1 Organism: Homo Sapiens
+ ARHGEF12up-regulates img/direct-activation.png guanine nucleotide exchange factor RHOA 0.902
Publications: 1 Organism: Homo Sapiens