Summary

Name PAK5
Full Name Serine/threonine-protein kinase PAK 5
Synonyms p21-activated kinase 5, PAK-5, p21-activated kinase 7, PAK-7 | KIAA1264, PAK5
Primary ID Q9P286
Links - -
Type protein
Relations 3
Function Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions.

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation PAK5
Publications: 2 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation BAD 0.59
Publications: 1 Organism: Chlorocebus Aethiops