3.0
Summary
| Name |  DDX5View Modifications |
| Full Name | Probable ATP-dependent RNA helicase DDX5 |
| Synonyms | DEAD box protein 5, RNA helicase p68 | G17P1, HELR, HLR1 |
| Primary ID | P17844 |
| Links |  -  -  |
| Type | protein |
| Relations | 13 |
| Function | Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as transcriptional repressor in a promoter-specific manner; the function probably involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PIAS1 | up-regulates 
sumoylation
|
DDX5 | 0.526 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PRKCA | down-regulates activity 
phosphorylation
|
DDX5 | 0.341 |
| Publications: | 1 | Organism: | In Vitro | |
| + | PAK5 | up-regulates quantity by stabilization
phosphorylation
|
DDX5 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ABL1 | up-regulates
phosphorylation
|
DDX5 | 0.366 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | DDX5 | up-regulates
binding
|
RUNX2 | 0.466 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | DDX5 | up-regulates
binding
|
AR | 0.326 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | DDX5 | up-regulates
binding
|
TP53 | 0.691 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | DDX5 | up-regulates quantity
post transcriptional regulation
|
mir-10b | 0.4 |
| Publications: | 1 | |||
| + | CBP/p300 | up-regulates
binding
|
DDX5 | 0.469 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | DDX5 | form complex 
binding
|
RNA helicases DDX5/DDX17 | 0.434 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | Muscle, Skeletal Muscle | |||
| + | DDX5 | up-regulates activity
binding
|
Microprocessor complex | 0.713 |
| Publications: | 1 | |||
| + | DDX5 | up-regulates
binding
|
HDAC1 | 0.401 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | rep | up-regulates activity
binding
|
DDX5 | |
| Publications: | 1 | Organism: | Homo Sapiens | |