Summary

Name FBLN5
Full Name Fibulin-5
Synonyms FIBL-5, Developmental arteries and neural crest EGF-like protein, Dance, Urine p50 protein, UP50 | DANCE
Primary ID Q9UBX5
Links - -
Type protein
Relations 3
Function Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN (PubMed:18185537). Stabilizes and organizes elastic fibers in the skin, lung and vasculature (By similarity). Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which may play a role in vascular development and remodeling (PubMed:10428823). May act as an adapter that mediates the interaction between FBN1 and ELN (PubMed:17255108).

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Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png binding ELN 0.753
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding ELN 0.753
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png binding FBLN5 0.398
Publications: 1 Organism: Homo Sapiens