| + |
FBN1 | up-regulates activity 
|
SMAD2 |
0.374 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251889 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17242066 |
Fibrillin-1 sequence encoded by exons 44-49 releases endogenous TGFbeta1, thereby stimulating TGFbeta receptor-mediated Smad2 signaling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DCN | up-regulates quantity by expression
transcriptional regulation
|
FBN1 |
0.578 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251893 |
|
|
Rattus norvegicus |
NRK Cell |
| pmid |
sentence |
| 17200203 |
Decorin Induces Fibrillin-1 Protein Expression in NRK Cells via IGF-IR. we report a novel mechanism of action that involves two key molecules: decorin, a small leucine-rich proteoglycan, and the IGF-IR. These two players, together with the downstream signaling pathway evoked by decorin-mediated activation of the receptor, lead to an enhanced translation of fibrillin-1 and its deposition in the extracellular environment both in vitro and in vivo. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
WNT3A | up-regulates quantity by stabilization
|
FBN1 |
0.277 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251894 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 17943183 |
Wnt3a markedly stimulated matrix assembly of microfibrillar proteins, including Fbn-1, by cultured fibroblasts, suggesting that Wnts contribute to increased microfibrillar matrices in Tsk skin.Wnt3a stimulates Fbn-1 matrix formation. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
IGF1 | up-regulates quantity by expression
transcriptional regulation
|
FBN1 |
0.296 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251862 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 17200203 |
Decorin and IGF-I induce fibrillin-1 protein synthesis in normal rat kidney fibroblasts |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
FBN1 | up-regulates quantity 
binding
|
TGFB1 |
0.504 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251888 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17242066 |
We have discovered that fibrillin-1, which forms extracellular microfibrils, can regulate the bioavailability of transforming growth factor (TGF) beta1, a powerful cytokine that modulates cell survival and phenotype. Altered TGFbeta signaling is a major contributor to the pathology of Marfan syndrome (MFS) and related diseases. In the presence of cell layer extracellular matrix, a fibrillin-1 sequence encoded by exons 44-49 releases endogenous TGFbeta1, thereby stimulating TGFbeta receptor-mediated Smad2 signaling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IGF1R | up-regulates quantity by expression
transcriptional regulation
|
FBN1 |
0.299 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251863 |
|
|
Rattus norvegicus |
NRK Cell |
| pmid |
sentence |
| 17200203 |
Decorin and IGF-I induce fibrillin-1 protein synthesis in normal rat kidney fibroblasts |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
all-cis-5,8,11,14,17-icosapentaenoic acid | up-regulates quantity by expression
|
FBN1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251910 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16467281 |
It was found that EPA increased collagen and elastic fibers (tropoelastin and fibrillin-1) expression by increasing transformin growth factor-beta expression in aged human skin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
LTBP2 | up-regulates activity
binding
|
FBN1 |
0.306 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251891 |
|
|
Homo sapiens |
Fibroblast |
| pmid |
sentence |
| 19681046 |
LTBP-2 interacts with fibrillin-1. The association of LTBP-2 with the ECM always coincided with that of fibrillin-1, and in fibroblast cultures the appearance of fibrillar fibrillin-1 structures preceded the assembly of LTBP-2 network. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FBN1 | down-regulates activity 
binding
|
FBLN5 |
0.398 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252138 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19570982 |
Fibulin-4 and -5 are extracellular glycoproteins with essential non-compensatory roles in elastic fiber assembly. We have determined how they interact with tropoelastin, lysyl oxidase, and fibrillin-1, thereby revealing how they differentially regulate assembly. Both fibulins differentially bound N-terminal fibrillin-1, which strongly inhibited their binding to lysyl oxidase and tropoelastin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL1A | down-regulates quantity by repression 
transcriptional regulation
|
FBN1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251890 |
|
|
Homo sapiens |
Fibroblast |
| pmid |
sentence |
| 9036927 |
UVB irradiation (50 mJ) of cultured skin fibroblasts suppressed fibrillin mRNA by 50%, consistent with a direct effect of radiation. UVB irradiation (50 mJ) of cultured skin fibroblasts suppressed fibrillin mRNA by 50%, consistent with a direct effect of radiation. Addition to the cultured fibroblasts of several cytokines upregulated by UVB showed that IL-1alpha had no effect on fibrillin mRNA in unirradiated cells, but in irradiated cells, this cytokine enhanced the suppression of fibrillin mRNA. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FBN1 | up-regulates quantity by expression
transcriptional regulation
|
MMP1 |
0.354 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251887 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16442122 |
In this study we show that a fibrillin-1 fragment containing a EGFEPG sequence that conforms to a putative GxxPG elastin-binding protein (EBP) consensus sequence upregulates the expression and production of matrix metalloproteinase (MMP)-1 by up to ninefold in a cell culture system. Mutations in the gene for fibrillin-1 cause Marfan syndrome (MFS), a common hereditary disorder of connective tissue |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FBN1 | down-regulates activity
binding
|
EFEMP2 |
0.402 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251860 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19570982 |
Fibulin-4 and -5 are extracellular glycoproteins with essential non-compensatory roles in elastic fiber assembly. Both fibulins differentially bound N-terminal fibrillin-1, which strongly inhibited their binding to lysyl oxidase and tropoelastin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
FBN1
- 
- 