Relation Results

Summary

Name LAMTOR3
Full Name Ragulator complex protein LAMTOR3
Synonyms Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3, MEK-binding partner 1, Mp1, Mitogen-activated protein kinase kinase 1-interacting protein 1, Mitogen-activated protein kinase scaffold protein 1 | MAP2K1IP1, MAPKSP1
Primary ID Q9UHA4
Links - -
Type protein
Relations 5
Function As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response ...
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Type: Score: Layout: SPV 
0.9310.6130.2530.6140.603LAMTOR3LAMTORMAP2K1ARHGAP8MEK1/2MAPK3

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Relations
Regulator
Mechanism
target
score ℹ
+ LAMTOR3form complex img/form-complex.png binding LAMTOR 0.931
Identifier Residue Sequence Organism Cell Line
SIGNOR-164775 Homo sapiens
pmid sentence
Mammals express four rag proteinsRaga, ragb, ragc, and ragdthat form heterodimers consisting of raga or ragb with ragc or ragd. Raga and ragb, like ragc and ragd, are highly similar to each other and are functionally redundant
Publications: 1 Organism: Homo Sapiens
+ LAMTOR3up-regulates img/direct-activation.png binding MAP2K1 0.613
Identifier Residue Sequence Organism Cell Line
SIGNOR-130924 Homo sapiens
pmid sentence
We analyzed the ability of mp1 to bind to mek1, erk1, and to itself, and the regulation of these interactions. Gel filtration of cell lysates revealed two major mp1 peaks: a broad high molecular weight peak and a 28 kda complex. An mp1 mutant that lost mek1 binding no longer enhanced rasv12-stimulated erk1 activity, and functioned as a dominant negative, consistent with the concept that mp1 function depends on facilitating these oligomerizations.
Publications: 1 Organism: Homo Sapiens
+ ARHGAP8up-regulates activity img/direct-activation.png binding LAMTOR3 0.253
Identifier Residue Sequence Organism Cell Line
SIGNOR-275551
pmid sentence
Furthermore, we identify that BPGAP1 (a BCH domain-containing, Cdc42GAP-like Rho GTPase-activating protein) promotes MEK partner 1 (MP1)-induced ERK activation on late endosome through scaffolding MP1/MEK1 complex. This regulatory function requires phosphorylation of BPGAP1 by JNK at its C terminal tail (Ser424) to unlock its autoinhibitory conformation.
Publications: 1
+ LAMTOR3up-regulates img/direct-activation.png binding MEK1/2 0.614
Identifier Residue Sequence Organism Cell Line
SIGNOR-244874 Homo sapiens
pmid sentence
We analyzed the ability of mp1 to bind to mek1, erk1, and to itself, and the regulation of these interactions. Gel filtration of cell lysates revealed two major mp1 peaks: a broad high molecular weight peak and a 28 kda complex. An mp1 mutant that lost mek1 binding no longer enhanced rasv12-stimulated erk1 activity, and functioned as a dominant negative, consistent with the concept that mp1 function depends on facilitating these oligomerizations.
Publications: 1 Organism: Homo Sapiens
+ LAMTOR3up-regulates img/direct-activation.png binding MAPK3 0.603
Identifier Residue Sequence Organism Cell Line
SIGNOR-59877 Homo sapiens
pmid sentence
A protein called mp1 (mek partner 1) was identified that bound specifically to mek1 and erk1 and facilitated their activation. When overexpressed in cultured cells, mp1 enhanced activation of erk1 and activation of a reporter driven by the transcription factor elk-1.
Publications: 1 Organism: Homo Sapiens
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