Summary

Name LAMTOR3
Full Name Ragulator complex protein LAMTOR3
Synonyms Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3, MEK-binding partner 1, Mp1, Mitogen-activated protein kinase kinase 1-interacting protein 1, Mitogen-activated protein kinase scaffold protein 1 | MAP2K1IP1, MAPKSP1
Primary ID Q9UHA4
Links - -
Type protein
Relations 5
Function As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.

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Relations

Regulator Mechanism target score ℹ
+ ARHGAP8up-regulates activity img/direct-activation.png binding LAMTOR3 0.255
Publications: 1
+ LAMTOR3form complex img/form-complex.png binding LAMTOR 0.929
Publications: 1 Organism: Homo Sapiens
+ LAMTOR3up-regulates img/direct-activation.png binding MAP2K1 0.599
Publications: 1 Organism: Homo Sapiens
+ LAMTOR3up-regulates img/direct-activation.png binding MEK1/2 0.6
Publications: 1 Organism: Homo Sapiens
+ LAMTOR3up-regulates img/direct-activation.png binding MAPK3 0.589
Publications: 1 Organism: Homo Sapiens