| + |
PLXNB3 | up-regulates activity 
binding
|
ARHGDIA |
0.255 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268435 |
|
|
Rattus norvegicus |
Glioma Cell |
| pmid |
sentence |
| 20696765 |
Here, we report the expression of plexin-B3 in glioma cells, which upon stimulation by its ligand Sema5A results in significant inhibition of cell migration and invasion. A search for the underlying mechanism revealed direct interaction of plexin-B3 with RhoGDP dissociation inhibitor α (RhoGDIα), a negative regulator of RhoGTPases that blocks guanine nucleotide exchange and sequesters them away from the plasma membrane. direct interaction of RhoGDIα and the cytoplasmic domain of plexin-B3 (plexin-B3CD) was confirmed by GST pulldown assays. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| Pathways: | Axon guidance |
| + |
SEMA5A | up-regulates activity
binding
|
PLXNB3 |
0.604 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268373 |
|
|
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 15218527 |
Plexin-B3 is a functional receptor for semaphorin 5A. Here we show that plexin-B3 is a high-affinity receptor specific for Sema5A. We further demonstrate that plexin-B3 activation by Sema5A mediates functional responses in plexin-B3-expressing cells (either fibroblasts, epithelial and primary endothelial cells). |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Axon guidance |
| + |
PLXNB3 | up-regulates activity 
|
FSCN1 |
0.34 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268374 |
|
|
Mus musculus |
Glioma Cell |
| pmid |
sentence |
| 21706053 |
Sema5A regulates the phosphorylation states of fascin-1 through plexin-B3. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Axon guidance |
3.0
PLXNB3
- 
- 