Summary

Name ARHGDIA
Full Name Rho GDP-dissociation inhibitor 1
Synonyms Rho GDI 1, Rho-GDI alpha | GDIA1
Primary ID P52565
Links - -
Type protein
Relations 7
Pathways Axon guidance
Function Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1.

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates img/direct_inhibition.png phosphorylation ARHGDIA 0.595
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ARHGDIA 0.359
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation ARHGDIA 0.415
Publications: 1 Organism: Homo Sapiens
Pathways:Axon guidance
+ up-regulates activity img/direct-activation.png binding ARHGDIA 0.254
Publications: 1 Organism: Rattus Norvegicus
Pathways:Axon guidance
+ down-regulates activity img/direct_inhibition.png guanine nucleotide exchange factor RAC1 0.802
Publications: 1 Organism: Rattus Norvegicus
Pathways:Axon guidance
+ up-regulates quantity by stabilization img/direct-activation.png polyubiquitination ARHGDIA 0.271
Publications: 1 Organism: Homo Sapiens