Relation Results

Summary

Name	CEP131
Full Name	Centrosomal protein of 131 kDa
Synonyms	5-azacytidine-induced protein 1, Pre-acrosome localization protein 1 \| AZI1, KIAA1118
Primary ID	Q9UPN4
Links	- -
Type	protein
Relations	1
Function	Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation (PubMed:17954613, PubMed:24185901). In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation (PubMed:24121310). In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner (PubMed:24121310, PubMed:26616734). Acts also as a negative regulator of BBSome ciliary trafficking (PubMed:24550735). Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail (By similarity). Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability in non-ciliogenic cells (PubMed:22797915, PubMed:26297806). Involved in centriole duplication (By similarity). Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). Essential for maintaining proper centriolar satellite integrity (PubMed:30804208). {ECO:0000250\|UniProtKB:Q62036, ECO:0000269\|PubMed:17954613, ECO:0000269\|PubMed:22797915, ECO:0000269\|PubMed:24121310, ECO:0000269\|PubMed:24185901, ECO:0000269\|PubMed:24550735, ECO:0000269\|PubMed:26297806, ECO:0000269\|PubMed:26616734, ECO:0000269\|PubMed:30804208}.